Publications de Martina Audagnotto

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Patrick Alain Sandoz, Florence Pojer, Matteo Dal Peraro, Sylvia Ho, Martina Audagnotto, Giulia Fonti, Maria Josefina Marcaida Lopez, Muhammad Umair Anwar, Francisco De Magalhães Sarmento R De Mesquita

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. ...

NATURE RESEARCH2021

CLoNe: automated clustering based on local density neighborhoods for application to biomolecular structural ensembles

Matteo Dal Peraro, Sylvain Träger, Martina Audagnotto, Giorgio Elikem Tamo, Deniz Aydin, Giulia Fonti

Motivation: Proteins are intrinsically dynamic entities. Flexibility sampling methods, such as molecular dynamics or those arising from integrative modeling strategies, are now commonplace and enable the study of molecular conformational landscapes in many ...

OXFORD UNIV PRESS2021

Recruitment of the amyloid precursor protein by gamma-secretase at the synaptic plasma membrane

Matteo Dal Peraro, Martina Audagnotto, Alexander Kengo Lorkowski

2018

Studying membrane-protein interplay by modeling realistic conditions

Martina Audagnotto

Realistic models of cellular environments have long captured the imagination of biologists and physical scientists. More than 20 years ago, Goodshellâ s inspiring rendering of cellular environments provided the foundation for the idea of capturing the ful ...

EPFL2017

Effect of the Synaptic Plasma Membrane on the Stability of the Amyloid Precursor Protein Homodimer

Thomas Lemmin, Matteo Dal Peraro, Alessandro Barducci, Martina Audagnotto

The proteolytic cleavage of the transmembrane (TM) domain of the amyloid precursor protein (APP) releases amyloid-beta (A beta) peptides, which accumulation in the brain tissue is an early indicator of Alzheimer's disease. We used multiscale molecular dyna ...

Amer Chemical Soc2016

New Insight into the Catalytic and Inhibition Mechanism of the Human Acyl Protein Thioesterase

Françoise Gisou van der Goot Grunberg, Patrick Alain Sandoz, Matteo Dal Peraro, Sylvia Ho, Martina Audagnotto, Nicole Andenmatten

Cell Press2016

Insights into the Stabilizing role of Cholesterol for the Amyloid Precursor Protein

Matteo Dal Peraro, Martina Audagnotto

Cell Press2015