Frédéric Bruno Martin Gachon

Cette personne n’est plus à l’EPFL

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Publications associées (29)

Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

Frédéric Bruno Martin Gachon

Most organisms, including humans, have developed an intrinsic system of circadian oscillators, allowing the anticipation of events related to the rotation of Earth around its own axis. The mammalian circadian timing system orchestrates nearly all aspects o ...

Endocrine Soc2017

Guidelines for Genome-Scale Analysis of Biological Rhythms

Felix Naef, Frédéric Bruno Martin Gachon, Zheng Chen, Alaaddin Bulak Arpat, Xiaodong Li, Han Wang

Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. These methods ...

Sage Publications Inc2017

Demonstration of the rhythmic physiology of the liver by nuclear proteomics

Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon

Edp Sciences S A2017

Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Meltem Weger

Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabolism. Here, we exa ...

Public Library Science2016

Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism

Cédric Gobet, Sylviane Métairon, Celine Jouffe, Frédéric Bruno Martin Gachon, Mojgan Masoodi

Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative feedback ...

Nature Research2016

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

Felix Naef, Patrick Descombes, Cédric Gobet, Jingkui Wang, Florian Atger, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living organisms. Such oscillations are controlled by the interplay between the circadian clock and feeding rhythms. Although rhythmic mRNA accumulation has been exte ...

National Academy of Sciences2015

Proteomics and circadian rhythms: It's all about signaling!

Loïc Dayon, Martin Kussmann, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon

Proteomic technologies using MS offer new perspectives in circadian biology, in particular the possibility to study PTMs. To date, only very few studies have been carried out to decipher the rhythmicity of protein expression in mammals with large-scale pro ...

Wiley-Blackwell2015

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Felix Naef, Jingkui Wang, Florian Atger, Celine Jouffe, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known ab ...

National Academy of Sciences2014

The Circadian Clock Coordinates Ribosome Biogenesis

Felix Naef, Laura Symul, Florian Atger, Celine Jouffe, Frédéric Bruno Martin Gachon

Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transc ...

Public Library Science2013

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