Publications de Naser Nasrollahzadeh Mamaghani

Helmet material design for mitigating traumatic axonal injuries through AI-driven constitutive law enhancement

Dominique Pioletti, Pierre-Etienne Bourban, Naser Nasrollahzadeh Mamaghani, Vincent Marc Varanges

Sports helmets provide incomplete protection against brain injuries. Here we aim to improve helmet liner efficiency by employing a novel approach that optimizes their properties. By exploiting a finite element model that simulates head impacts, we develope ...

2025

Design of Customized Mouthguards with Superior Protection Using Digital-Based Technologies and Impact Tests

Dominique Pioletti, Martin Broome, Naser Nasrollahzadeh Mamaghani

Background In contact sports, an impact on the jaw can generate destructive stress on the tooth-bone system. Mouthguards can be beneficial in reducing the injury risk by changing the dynamics of the trauma. The material properties of mouthguards and their ...

Springer2024

Customized modular multi-material mouthguard and method of making the same

Dominique Pioletti, Martin Broome, Naser Nasrollahzadeh Mamaghani

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property ...

2024

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Jian Wang, Yanheng Guo

During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react a ...

eLIFE SCIENCES PUBL LTD2022

Loading Induced Self-Heating Of Articular Cartilage And Associated Signaling Mechanism

Dominique Pioletti, Lee Ann Laurent-Applegate, Naser Nasrollahzadeh Mamaghani

MARY ANN LIEBERT, INC2022

Development Of A 3D Piezo-Biomaterial To Study Cartilage Electro-Mechanobiology

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Lida Bagheri

MARY ANN LIEBERT, INC2022

An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Naser Nasrollahzadeh Mamaghani, Peyman Karami

Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary ...

WILEY-V C H VERLAG GMBH2021

The role of mechanical hysteresis source in mechanical and mechanobiological performances of load-bearing biomaterials

Naser Nasrollahzadeh Mamaghani

Tissue engineering is a promising approach for articular cartilage regeneration as no satisfactory treatment is actually available for cartilage, partly due to the very limited self-healing capability of this tissue. To successfully induce a cartilaginous ...

EPFL2019

Control of Dissipation Sources: A Central Aspect for Enhancing the Mechanical and Mechanobiological Performances of Hydrogels

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami

Development of mechanically durable and biologically inductive hydrogels is a major challenge for load-bearing applications such as engineered cartilage. Dissipative capacity of articular cartilage is central to its functional behavior when submitted to lo ...

2019

Development of an effective cell seeding technique: simulation, implementation and analysis of contributing factors

Dominique Pioletti, Lee Ann Laurent-Applegate, Naser Nasrollahzadeh Mamaghani

Cell seeding in a biomaterial is an important process for tissue engineering applications. It helps to modulate tissue formation or to control initial conditions for mechanobiological studies. The compression release-induced suction (CRIS) seeding techniqu ...

Mary Ann Liebert, Inc2017

Experimental method to characterize the strain dependent permeability of tissue engineering scaffolds

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani

Permeability is an overarching mechanical parameter encompassing the effects of porosity, pore size, and interconnectivity of porous structures. This parameter directly influences transport of soluble particles and indirectly regulates fluid pressure and v ...

Elsevier2016