Publications de Flavia Aurelia Shoko Hodel

Prevalence of actionable pharmacogenetic variants in a Swiss hospital cohort

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Axel Wandall Thorball, Maria De Min

Springernature2024

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 ...

2024

Prevalence of actionable pharmacogenetic variants and high-risk drug prescriptions: A Swiss hospital-based cohort study

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Axel Wandall Thorball

Drug type and dosing recommendation have been designed and optimized based on average response in the general population. Yet, there is significant inter-individual variability in drug response, which results in treatment inefficacy or adverse drug reactio ...

WILEY2024

Associations of genetic and infectious risk factors with coronary heart disease

Roxane De La Harpe, Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Axel Wandall Thorball, Zhi Ming Xu

Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...

eLIFE SCIENCES PUBL LTD2023

Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Flavia Aurelia Shoko Hodel, Albulena Jashari-Shaqiri, Janir Nuno Ramos Antunes Da Cruz

Schizophrenia is a severe psychiatric disorder determined by a complex mixture of genetic and environmental factors. To better understand the contributions of human genetic variations to schizophrenia, we performed a genome-wide association study (GWAS) of ...

2022

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

Flavia Aurelia Shoko Hodel

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

EPFL2022

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Flavia Aurelia Shoko Hodel, Olivier Noël Marie Naret, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

Improving polygenic prediction with genetically inferred ancestry

Jacques Fellay, Flavia Aurelia Shoko Hodel, Olivier Noël Marie Naret, Zhi Ming Xu

Genome-wide association studies (GWASs) have demonstrated that most common diseases have a strong genetic component from many genetic variants each with a small effect size. GWAS summary statistics have allowed the construction of polygenic scores (PGSs) e ...

ELSEVIER2022

Human genomics of the humoral immune response against polyomaviruses

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Christian Axel Wandall Thorball, Olivier Noël Marie Naret, Zhi Ming Xu

Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of the humoral immune response against polyomaviruses, we performed genome-wide association studies and meta ...

OXFORD UNIV PRESS2021

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Christian Axel Wandall Thorball, Zhi Ming Xu

SPRINGERNATURE2020

An indel in the promoter region of NFKB1 confers protection against infection but increases risk of allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

SPRINGERNATURE2020

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic

Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...

2019

Human genetic determinants of chronic low-grade inflammation in the general population

Jacques Fellay, Flavia Aurelia Shoko Hodel

NATURE PUBLISHING GROUP2019

Predicting the Occurrence of Variants in RAG1 and RAG2

Jacques Fellay, Flavia Aurelia Shoko Hodel, Dylan Lawless

While widespread genome sequencing ushers in a new era of preventive medicine, the tools for predictive genomics are still lacking. Time and resource limitations mean that human diseases remain uncharacterized because of an inability to predict clinically ...

2019

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Maya Roinishvili, Jacques Fellay, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi, Christian Axel Wandall Thorball

2018