Publications de Hatice Altug | EPFL Graph Search

High-Throughput Fabrication of Microscale Gold Nanoparticle Superstructures with Tunable Plasmonic Coupling for Ultrasensitive SERS Detection

American Chemical Society (ACS)2025

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases

Hilal Lashuel, Hatice Altug, Deepthy Kavungal

The misfolding of proteins from native monomers into β-sheet-rich fibrils via oligomers is a key hallmark of neurodegenerative diseases (NDDs). Identifying and screening drugs that inhibit protein aggregation for early disease intervention remains challeng ...

2025

Plasmonic biosensor enabled by resonant quantum tunnelling

Hatice Altug

Metasurfaces provide an ideal platform for optical sensing because they produce strong light-field confinement and enhancement over extended regions that allow us to identify deep-subwavelength layers of organic and inorganic molecules. However, the requir ...

Nature Publishing Group2025

Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs

Hatice Altug

We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore t ...

2025

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-fluorescence Imaging

Matthias Lütolf, Hatice Altug, Yen-Cheng Liu, Saeid Ansaryan, Luis Francisco Lorenzo Martin

Advances in organoid models, as ex vivo mini-organs, and the development of screening imaging technologies have continuously driven each other forward. A complete understanding of organoids requires detailed insights into the intertwined intraorganoid and ...

WILEY-V C H VERLAG GMBH2025

Plasmon-Enhanced Circular Dichroism for Enantiomeric Discrimination of Chiral Drug Solutions

Hatice Altug

We analyze surface plasmon polaritons at noble metal interfaces for enhancing chiroptical sensing of dilute chiral drug solutions. Circular dichroism is amplified by plasmonic resonances to attain sensitivity to nano-scale drug volumes, demonstrating great ...

IEEE2025

Enhanced Vibrational Circular Dichorism of Plasmonic Nanostructures Embedding Chiral Drugs

Hatice Altug

We explore the potential applications of localized surface plasmon resonances (LSPRs) to investigate mid-infrared chiroptical response of Al-doped ZnO (AZO)-based nanostructures embedding layers of chiral pharmaceutical drug solutions to develop novel chir ...

IEEE2025

Optical Metasurfaces for the Next-Generation Biosensing and Bioimaging

Hatice Altug

Recent advances in this understanding of light-matter interactions, combined with innovations in the design and fabrication of large-scale nanostructured metasurfaces, have enabled transformative approaches to biosensing and bioimaging. This review delves ...

2025

Plasmon-Enhanced Optical Rotation and Circular Dichroism in Near-Zero Index Chiral Metamaterial

Hatice Altug

We investigate plasmon-enhanced optical rotation and circular dichroism in a near-zero-index metamaterial composed of metallic nanospheres randomly dispersed in a chiral drug solution. ...

IEEE2025

Multimodal Nanoplasmonic and Fluorescence Imaging for Simultaneous Monitoring of Single-Cell Secretory and Intracellular Dynamics

Hatice Altug, Yen-Cheng Liu, Saeid Ansaryan

Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics in a spatially and temporally resolved manner. This study presents a multimodal imaging system that integrates nanoplasmonic sen ...

WILEY2025

Chirality encoding in resonant metasurfaces governed by lattice symmetries

Hatice Altug, Felix Ulrich Richter

Chiral metasurfaces provide invaluable tools for controlling structured light required for biosensing, photochemistry, holography, and quantum photonics. Here we suggest and realize a universal strategy for engineering chiral response of resonant metasurfa ...

Springer Science and Business Media LLC2025

Magnesium Optrodes for Real-Time Optical Monitoring of Water Transport in Ultrathin Encapsulations for Bioelectronics

Yves Leterrier, Stéphanie Lacour, Hatice Altug, Deepthy Kavungal, Massimo Mariello

Recent studies investigated the hydrolysis of Magnesium (Mg) thin films, highlighting their potential use in biodegradable devices. Quantitatively monitoring the degradation rate and morphological changes of Mg through optical methods and light-delivery de ...

2024

Bioinspired Three-Component System to Prepare Full-Color Functional Biomimetic Pigments

Hatice Altug

Nature provides a great source of inspiration for the development of sustainable materials with excellent properties, among which melanin with optical, electronic, and radiation protection properties are considered to be promising coloring materials. Howev ...

AMER CHEMICAL SOC2024

Long-Term and Continuous Plasmonic Oligonucleotide Monitoring Enabled by Regeneration Approach

Hatice Altug, Saeid Ansaryan

The demand for continuous monitoring of biochemical markers for diagnostic purposes is increasing as it overcomes the limitations of traditional intermittent measurements. This study introduces a method for long-term, continuous plasmonic biosensing of oli ...

Wiley-VCH Verlag GmbH2024

Continuous Biosensing to Monitor Acute Systemic Inflammation, a Diagnostic Need for Therapeutic Guidance

Hatice Altug

Continuous monitoring of acute inflammation can become a very important next step for guiding therapeutic interventions in severely ill patients. This Perspective discusses the current medical need for patients with acute inflammatory diseases and the pote ...

AMER CHEMICAL SOC2024

Deep learning augmented nanoplasmonic infrared sensor for structural protein biomarker-based detection of neurodegenerative diseases

Hilal Lashuel, Hatice Altug, Deepthy Kavungal, Rajasekhar Kolla, Pedro José Santana Ribeiro Magalhães

We introduce an infrared metasurface sensor based on plasmonic surface-enhanced infrared absorption spectroscopy combined with immunoassay, which detects alpha-synuclein, an early structural biomarker protein for neurodegenerative diseases with clinical sp ...

SPIE2024

Optical biosensors towards the clinic

Hatice Altug

Nature Photonics spoke with Hatice Altug, from the & Eacute;cole Polytechnique F & eacute;d & eacute;rale de Lausanne (EPFL), Thomas Krauss, from the University of York, and Malini Olivo from the Agency for Science, Technology and Research (A*STAR) about o ...

Nature Publishing Group2024

Gradient High-Q Dielectric Metasurfaces for Broadband Sensing and Control of Vibrational Light-Matter Coupling

Hatice Altug, Aleksandrs Leitis, Felix Ulrich Richter

Surface-enhanced infrared absorption spectroscopy (SEIRA) has emerged as a powerful technique for ultrasensitive chemical-specific analysis. SEIRA can be realized by employing metasurfaces that can enhance light-matter interactions in the spectral bands of ...

Wiley-V C H Verlag Gmbh2024

Stepwise release of Activin-A from its inhibitory prodomain is modulated by cysteines and requires furin coexpression to promote melanoma growth

Daniel Constam, Pierpaolo Ginefra, Hatice Altug, Benjamin Marcel Daniel Rothé, Céline Emmanuelle Schmuziger, Manon Bulliard, Katarina Pinjusic, Saeid Ansaryan

The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and how it facilitates access to signaling receptors is unclear. Here, analysis in a syngeneic melanoma grafting model shows that without furin ...

2024

Challenges and perspectives of CRISPR-based technology for diagnostic applications

Hatice Altug

The precision and versatility of CRISPR-based techniques, combined with the advantages of nucleic acid-based nanotechnology, hold great promise in transforming the landscape of molecular diagnostics. While significant progress has been made, current CRISPR ...

Elsevier Sci Ltd2024