Publications de Keir Joe Menzies

Repairing Mitochondrial Dysfunction in Disease

Johan Auwerx, Keir Joe Menzies, Vincenzo Sorrentino

2018

The role of mitochondria in stem cell fate and aging

Johan Auwerx, Hongbo Zhang, Keir Joe Menzies

2018

A multiscale study of the role of dynamin in the regulation of glucose uptake

Martinus Gijs, Kristina Schoonjans, Johan Auwerx, Laurent Mouchiroud, Keir Joe Menzies, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where c ...

Royal Soc Chemistry2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Elena Katsyuba, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Alessia Perino, Karim Laurent Gariani, Vera Monica Lemos Da Silva, Pooja Jha, Jun Yong Kim

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...

2017

Agents and methods using thereof for the prevention and treatment of stem cells senescence

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...

2017

NAD(+) repletion improves muscle function in muscular dystrophy and counters global PARylation

Johan Auwerx, Carlos Canto Alvarez, Dongryeol Ryu, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Vincenzo Sorrentino

Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to ...

Amer Assoc Advancement Science2016

Protein acetylation in metabolism - metabolites and cofactors

Elena Katsyuba, Johan Auwerx, Hongbo Zhang, Keir Joe Menzies

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...

Nature Publishing Group2016

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Matthias Lütolf, Ruedi Aebersold, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Karim Laurent Gariani, Xu Wang, Peiling Luan, Davide D'Amico

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its imp ...

American Association for the Advancement of Science2016

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Johan Auwerx, Carlos Canto Alvarez, Keir Joe Menzies

NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived intere ...

Cell Press2015

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Norman Lionel Moullan, Evan Graehl Williams, Eija Riitta Pirinen, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Cell Press2014

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Chikage Mataki, Dongryeol Ryu, Maaike Hélène Oosterveer, Pan Xu, Keir Joe Menzies, Alessia Perino, Xu Wang, Vera Monica Lemos Da Silva

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Kristina Schoonjans, Johan Auwerx, Hiroyasu Yamamoto, Adrienne Joëlle Laurence Mottis, Giuseppe Lo Sasso, Alessandra Piersigilli, Keir Joe Menzies, Alessia Perino

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

An acetylation rheostat for the control of muscle energy homeostasis

Johan Auwerx, Keir Joe Menzies

In recent years, the role of acetylation has gained ground as an essential modulator of intermediary metabolism in skeletal muscle. Imbalance in energy homeostasis or chronic cellular stress, due to diet, aging, or disease, translate into alterations in th ...

Society for Endocrinology2013