Publications de Amélie Barbara Hildegarde Béduer

An Injectable Meta-Biomaterial: From Design and Simulation to In Vivo Shaping and Tissue induction

Patrick Burch, Amélie Barbara Hildegarde Béduer, Martina Genta

A novel type of injectable biomaterial with an elastic softening transition is described. The material enables in vivo shaping, followed by induction of 3D stable vascularized tissue. The synthesis of the injectable meta-biomaterial is instructed by extens ...

Wiley-V C H Verlag Gmbh2021

Device and process for tissue-engineering and regenerative medicine

Thomas Michael Braschler, Olaia Maria Naveiras Torres-Quiroga, Amélie Barbara Hildegarde Béduer, Josefine Catharina Pedersen Tratwal, Martina Genta, Daniel Naveed Tavakol

A process and device for direct in-vitro to in-vivo transfer of a living microcarrier culture by controlled dehydration into a viscoelastic material capable of cell-protection during delivery. One particular purpose of the present invention is that of prov ...

2021

Injectable, scalable 3D tissue-engineered model of marrow hematopoiesis

Patrick Burch, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos, Amélie Barbara Hildegarde Béduer, Josefine Catharina Pedersen Tratwal, Martina Genta, Daniel Naveed Tavakol

2019

Particle suitable for the manufacture of an implantable soft tissue engineering material

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompati ...

2019

Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

Philippe Renaud, Arnaud Bertsch, Ariane Rochat, Thomas Michael Braschler, Ludovic Serex, Amélie Barbara Hildegarde Béduer, Aleksandra Filippova

Cryogels are macroporous materials that display remarkable properties, such as high pore interconnection, large surface to volume ratio, and high mechanical stability, making them good candidates for 3D cell culture. However, shaping cryogels remains chall ...

Wiley2018

Cryogel 3d scaffolds and methods for producing thereof

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric ...

2018

Shapeable scaffold material and uses thereof

Philippe Renaud, Thomas Michael Braschler, Giorgio Pietramaggiori, Amélie Barbara Hildegarde Béduer

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

2017

Ophthalmic contact lens with a compressible affinity matrix

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutral ...

2016

Detection of Alzheimer’s disease amyloid-beta plaque deposition by deep brain impedance profiling

Philippe Renaud, Patrick Fraering, Pierre Joris, Sébastien Mosser, Amélie Barbara Hildegarde Béduer

OBJECTIVE: Alzheimer disease (AD) is the most common form of neurodegenerative disease in elderly people. Toxic brain amyloid-beta (ASS) aggregates and ensuing cell death are believed to play a central role in the pathogenesis of the disease. In this study ...

Iop Publishing Ltd2015

A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks

Philippe Renaud, Thomas Michael Braschler, Patrick Fraering, Oliver Peric, Georg Fantner, Sébastien Mosser, Amélie Barbara Hildegarde Béduer, Sidi Ahmed Bencherif

Millimeter to centimeter-sized injectable neural scaffolds based on macroporous cryogels are presented. The polymer-scaffolds are made from alginate and carboxymethyl-cellulose by a novel simple one-pot cryosynthesis. They allow surgical sterility by means ...

Wiley-VCH Verlag2015

Accurate resistivity mouse brain mapping using microelectrode arrays

Philippe Renaud, Vincent Delattre, Patrick Fraering, Pierre Joris, Sébastien Mosser, Amélie Barbara Hildegarde Béduer

Electrical impedance spectroscopy measurements were performed in post-mortem mice brains using a flexible probe with an embedded micrometric electrode array. Combined with a peak resistance frequency method this allowed obtaining intrinsic resistivity valu ...

Elsevier2014