Publications de Alessia Perino

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Alessia Perino, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Rizlan Bernier-Latmani, Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Eduard Vico Oton, Colin Volet, Antoine Jalil

Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7 alpha-dehydroxylated bile acids are notably diminished in inflammatory bowel diseas ...

SPRINGERNATURE2025

Protecting liver health with microbial-derived succinylated bile acids

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

The gut microbiome produces a plethora of metabolites that influence host metabolism. In a recent article published in Cell, Nie and colleagues reveal that 3-succinylated cholic acid, a microbe-derived bile acid, protects against metabolic dysfunction-asso ...

OXFORD UNIV PRESS2024

A microbial-derived succinylated bile acid to safeguard liver health

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny

In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...

Cell Press2024

Wars1 downregulation in hepatocytes induces mitochondrial stress and disrupts metabolic homeostasis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Hadrien Charles Edouard Demagny, Xiaoxu Li, Antoine Jalil

Several laboratories, including ours, have employed the Slc25a47tm1c(EUCOMM)Hmgu mouse model to investigate the role of SLC25A47, a hepatocyte-specific mitochondrial carrier, in regulating hepatic metabolism and systemic physiology. In this study, we revea ...

2024

An antibiotic and a microorganism having bile acid 7α-dehydroxylation activity for treating non-infectious diseases

Kristina Schoonjans, Alessia Perino, Antoine Jalil

The present invention relates to one or more antibiotic(s) that disrupt(s) the microbial balance of the gut and a microorganism having bile acid 7α-dehydroxylation activity for use in the treatment of a non-infectious disease in a subject. ...

2024

The Bile Acid Receptor Tgr5 Regulates The Composition And Hematopoietic Support Capacity Of The Bone Marrow Microenvironment

Kristina Schoonjans, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

ELSEVIER SCIENCE INC2023

Role of TGR5 in fat-to-liver communication during NAFLD

Kristina Schoonjans, Alessia Perino

ELSEVIER2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Ulrike Kettenberger, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

Smw Supporting Association2023

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Ece Yildiz, Hadrien Charles Edouard Demagny, Nadia Bresciani, Yu Sun, Antoine Jalil

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Jean-David Horacio Morel, Xiaoxu Li

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam, Antoine Jalil

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Vera Monica Lemos Da Silva, Hao Li, Hadrien Charles Edouard Demagny, Nadia Bresciani, Yu Sun, Xiaoxu Li

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Bile acids after bariatric surgery: a gateway to mitochondrial activation in human adipocytes

Kristina Schoonjans, Alessia Perino

SPRINGER2022

Metabolic Messengers: bile acids

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their action ...

2022

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Amir Banaei Esfahani, Karim Laurent Gariani, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Qingyao Huang, Laura Alejandra Velazquez Villegas, Yu Sun, Xiaoxu Li, Ludger Jan Elzuë Goeminne

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Kristina Schoonjans, Alessia Perino

Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well-documented previously. This study investigates how busulfa ...

WILEY2022

Short Article Hypothalamic bile acid-TGR5 signaling protects from obesity

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implic ...

Cell Press2021

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

Central anorexigenic actions of bile acids are mediated by TGR5

Kristina Schoonjans, Alessia Perino, Qingyao Huang, Laura Alejandra Velazquez Villegas, Nadia Bresciani, Yu Sun

Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain, yet their physiological role in the central nervous system is ...

2021