Publications de Alexander Belushkin

Nanoparticle-enhanced Imaging Based Plasmonic Biosensor

Efficient medical care fundamentally relies on the ability to provide a timely and accurate diagnosis. Thanks to advances in biomedical research, specific molecules called diagnostic molecular biomarkers have been discovered in the human body that help ind ...

EPFL2020

An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, George Coukos, Maria Soler Aznar

An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubat ...

IEEE2019

Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor

Hatice Altug, Alexander Belushkin

y Sepsis is a condition characterized by a severe stage of blood-infection often leading to tissue damage, organ failure and finally death. Fast diagnosis and identification of the sepsis stage (sepsis, severe sepsis or septic shock) is critical for the pa ...

ELSEVIER SCIENCE BV2019

Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...

AMER CHEMICAL SOC2019

Integrated Nanophotonic Biosensors for Point-of Care Diagnostics and Bioanalytical Applications

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Yasaman Jahani

In an effort to address the requirements of next-generation healthcare systems, including personalized medicine, point-of-care diagnostics, and global health surveillance, I will introduce imaging-based portable nanoplasmonic biosensors integrated with mic ...

IEEE2019

Plasmonic biosensor

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light pro ...

2019

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

New point-of-care diagnostic devices are urgently needed for rapid and accurate diagnosis, particularly in the management of life-threatening infections and sepsis, where immediate treatment is key. Sepsis is a critical condition caused by systemic respons ...

2019

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasm ...

2018

Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...

2018

Towards a point-of-care nanoplasmonic biosensor for rapid and multiplexed detection of pathogenic infections

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Optofluidic nanoplasmonic biosensor for label-free live cell analysis in real time

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

Cell signaling activities play a critical role in physiological and disease processes. The analysis of the tumor microenvironment or the immune system activation is nowadays providing valuable insights towards disease understanding and novel therapies deve ...

2018

Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar, Cenk Ibrahim Özdemir

Cell secretion dynamics plays a central role in physiological and disease processes. Due to its various temporal profiles, it is essential to implement a precise detection scheme for continuous monitoring of secretion in real time. The current fluorescent ...

Royal Society of Chemistry2017

Multiplexed nanoplasmonic biosensor for one-step simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine

Andrea Cavallini, Hatice Altug, Alexander Belushkin, Maria Soler Aznar

Development of rapid and multiplexed diagnostic tools is a top priority to address the current epidemic problem of sexually transmitted diseases. Here we introduce a novel nanoplasmonic biosensor for simultaneous detection of the two most common bacterial ...

2017