Publications de Filiz Yesilköy

Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles

Michele De Palma, Hatice Altug, Chiara Cianciaruso, Filiz Yesilköy, Yasaman Jahani, Eduardo Romero Arvelo

Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and treatment monitoring to preventing pandemics. We introduce single-wavelength imaging biosensors capab ...

Nature Research2021

An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, George Coukos, Maria Soler Aznar

An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubat ...

IEEE2019

Ultrasensitive hyperspectral imaging and biodetection enabled by dielectric metasurfaces

Volkan Cevher, Hatice Altug, Filiz Yesilköy, Andreas Tittl, Yasaman Jahani, Eduardo Romero Arvelo, Mingkai Liu

Metasurfaces based on resonant subwavelength photonic structures enable novel ways of wavefront control and light focusing, underpinning a new generation of flat-optics devices. Recently emerged all-dielectric asymmetric metasurfaces, composed of arrays of ...

Nature Publishing Group2019

Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. Here we report a portable PoC devi ...

AMER CHEMICAL SOC2019

Integrated Nanophotonic Biosensors for Point-of Care Diagnostics and Bioanalytical Applications

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Yasaman Jahani

In an effort to address the requirements of next-generation healthcare systems, including personalized medicine, point-of-care diagnostics, and global health surveillance, I will introduce imaging-based portable nanoplasmonic biosensors integrated with mic ...

IEEE2019

Plasmonic biosensor

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light pro ...

2019

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

New point-of-care diagnostic devices are urgently needed for rapid and accurate diagnosis, particularly in the management of life-threatening infections and sepsis, where immediate treatment is key. Sepsis is a critical condition caused by systemic respons ...

2019

Self-assembly of nanostructured glass metasurfaces via templated fluid instabilities

Hatice Altug, Dang Tùng Nguyen, Fabien Sorin, Filiz Yesilköy, Alexis Gérald Page, Wei Yan, Arthur Le Bris, Yunpeng Qu, Louis Marie Philippe Martin-Monier, Kuan-Ting Ho

Modern devices require the tuning of the size, shape and spatial arrangement of nano-objects and their assemblies with nanometre-scale precision, over large-area and sometimes soft substrates. Such stringent requirements are beyond the reach of conventiona ...

Nature Publishing Group2019

All-dielectric Metasurfaces for Infrared Absorption Spectroscopy Applications

Hatice Altug, Filiz Yesilköy, Andreas Tittl, Aleksandrs Leitis, Mingkai Liu

We present a nanophotonic method capable of detecting mid-infrared molecular fingerprints without the need for spectrometry, frequency scanning, or moving mechanical parts. We leverage dielectric metasurfaces featuring ultra-sharp resonances each tuned to ...

IEEE2019

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Optofluidic nanoplasmonic biosensor for label-free live cell analysis in real time

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

Cell signaling activities play a critical role in physiological and disease processes. The analysis of the tumor microenvironment or the immune system activation is nowadays providing valuable insights towards disease understanding and novel therapies deve ...

2018

Nanoparticle-Enhanced Plasmonic Biosensor for Digital Biomarker Detection in a Microarray

Hatice Altug, Alexander Belushkin, Filiz Yesilköy

Nanoplasmonic devices have become a paradigm for biomolecular detection enabled by enhanced light–matter interactions in the fields from biological and pharmaceutical research to medical diagnostics and global health. In this work, we present a bright-fiel ...

2018

Imaging-based molecular barcoding with pixelated dielectric metasurfaces

Hatice Altug, Filiz Yesilköy, Andreas Tittl, Aleksandrs Leitis, Mingkai Liu

Metasurfaces provide opportunities for wavefront control, flat optics, and subwavelength light focusing. We developed an imaging-based nanophotonic method for detecting mid-infrared molecular fingerprints and implemented it for the chemical identification ...

American Association for the Advancement of Science2018

Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Yasaman Jahani

Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasm ...

2018

Towards a point-of-care nanoplasmonic biosensor for rapid and multiplexed detection of pathogenic infections

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar, Cenk Ibrahim Özdemir

Cell secretion dynamics plays a central role in physiological and disease processes. Due to its various temporal profiles, it is essential to implement a precise detection scheme for continuous monitoring of secretion in real time. The current fluorescent ...

Royal Society of Chemistry2017