Publications de Emmanuel Louis Arthur Gerelli

Study and optimization of the photobiomodulation effects induced on mitochondrial metabolic activity of human cardiomyocytes for different radiometric and spectral conditions

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

Photobiomodulation (PBM) represents a promising and powerful approach for non-invasive therapeutic interventions. This emerging field of research has gained a considerable attention due to its potential for multiple disciplines, including medicine, neurosc ...

2024

Identification of excimer delayed fluorescence by Protoporphyrin IX: A novel access to local chromophore concentration?

Georges Wagnières, Aurelien Stephen Arnaud Gregor, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

Protoporphyrin IX (PpIX) is a molecule produced in the mitochondria following the administration of its approved precursor, aminolevulinic acid (ALA). Strong light absorber at different wavelengths in the visible range, PpIX is extensively used as a photos ...

ELSEVIER SCIENCE SA2022

Stimulation and homogenization of the protoporphyrin IX endogenous production by photobiomodulation to increase the potency of photodynamic therapy

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová, Cyrus Kazemiraad

Protoporphyrin IX (PpIX) is produced in the mitochondria and used as fluorescent contrast agent or photosensitizer after exogenous 5-aminolevulinic acid (ALA) delivery in cancer photodynamic detection and therapy (PDT). Although routinely used in the clini ...

ELSEVIER SCIENCE SA2021

A general framework for non-exponential delayed fluorescence and phosphorescence decay analysis, illustrated on Protoporphyrin IX

Georges Wagnières, Aurelien Stephen Arnaud Gregor, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

Delayed fluorescence (DF) is a long-lived luminescence process used in a variety of applications ranging from oxygen sensing in biological tissues to organic Light Emitting Diodes. In common cases, DF results from the deexcitation of the first excited trip ...

2020

Increase and homogenization of the endogenous production of protoporphyrin IX by photobiomodulation

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

Photodynamic therapy (PDT) and/or photodetection (PDD) based on protoporphyrin IX (PpIX) are used in many medical fields. However, the endogenous production of PpIX in tissues after administration of its precursor, 5-aminolevulinic acid (ALA) or derivative ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Measurements of the optical coefficients of the protoporphyrin IX endogenously producing yeast-based model in the visible and NIR

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

SPIE Society of Photo-optical Instrumentation Engineers2018

Modulation of the endogenous production of protoporphyrin IX in a yeast - based model organism

Georges Wagnières, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

The main aim of this study was to assess conditions at which simple yeast-based model organism produces maximal levels of protoporphyrin IX (PpIX) after an exogenous administration of its precursor, 5-aminolevulinic acid (ALA), and the ferrous-ion chelator ...

Spie-Int Soc Optical Engineering2017

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

Measurement of pO2 by luminescence lifetime spectroscopy: A comparative study of the phototoxicity and sensitivity of [Ru(Phen)3]2+ and PdTCPP in vivo

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

Dysfunctions in tissue metabolism can be detected at early stages by oxygen partial pressure (pO(2)) measurement. The measurement of emission lifetimes offers very promising and non-invasive approach to estimate pO(2) in vivo. This study compares two exten ...

Wiley-V C H Verlag Gmbh2016

Effect of PpIX photoproducts formation on pO2 measurement by time-resolved delayed fluorescence spectroscopy of PpIX in solution and in vivo

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The measurement of Protoporphyrin IX delayed fluorescence lifetime is a minimally invasive method for monitoring the levels of oxygen in cells and tissues. The excitation of Protoporphyrin IX during this measurement can lead to the formation of photoproduc ...

Elsevier Science Sa2016

Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Emmanuel Louis Arthur Gerelli, Jaroslava Joniová

The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...

SPIE Society of Photo-optical Instrumentation Engineers2016