Publications de Lisa Christina Metzger

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Lisa Christina Metzger, Natalia Carolina Drebes Dorr, Sandrine Natacha Isaac, Nicolas René Chiaruttini, Alexis Joseph Proutière, Loriane Bader

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

2023

Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species

Noémie Matthey, Melanie Blokesch, Esther Jeanne Collas, Candice Stoudmann, Lisa Christina Metzger

Bacteria of the genus Vibrio are common members of aquatic environments where they compete with other prokaryotes and defend themselves against grazing predators. A macromolecular protein complex called the type VI secretion system (T6SS) is used for both ...

2019

Regulation of competence-mediated horizontal gene transfer in the natural habitat of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

The human pathogen Vibrio cholerae is an autochthonous inhabitant of aquatic environments where it often interacts with zooplankton and their chitinous molts. Chitin induces natural competence for transformation in V. cholerae, a key mode of horizontal gen ...

Elsevier2016

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Noémie Matthey, Melanie Blokesch, Sandrine Stutzmann, Charles Ulric V Van der Henst, Tiziana Scrignari, Lisa Christina Metzger

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A recent ...

Elsevier2016

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer

Melanie Blokesch, Tiziana Scrignari, Lisa Christina Metzger

Natural competence for transformation is a common mode of horizontal gene transfer and contributes to bacterial evolution. Transformation occurs through the uptake of external DNA and its integration into the genome. Here, we show that the type VI secretio ...

American Association for the Advancement of Science2015

Composition of the DNA-uptake complex of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

Natural competence for transformation is a developmental program that allows certain bacteria to take up free extracellular DNA from the environment and integrate this DNA into their genome. Thereby, natural transformation acts as mode of horizontal gene t ...

2014

Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP)

Matteo Dal Peraro, Marco Stenta, Lisa Christina Metzger

The needle length of the Yersinia spp. injectisome is determined by Yop secretion protein P (YscP), an early substrate of the injectisome itself. There is a linear correlation between the length of YscP and the length of the needle, suggesting that YscP ac ...

National Academy of Sciences2010