Publications de Xiao Ji | EPFL Graph Search

Extending the lifetime of hyperpolarisation

In nuclear magnetic resonance (NMR), one of the most serious inherent challenges is the low sensibility of nuclei. In order to enhance the signal of NMR experiments, the technique of dynamic nuclear hyperpolarisation (DNP) was introduced in the 1950s, lead ...

EPFL2017

Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, Xiao Ji, David Lyndon Emsley, Aaron James Rossini

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Highly Repeatable Dissolution Dynamic Nuclear Polarization for Heteronuclear NMR Metabolomics

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji

At natural C-13 abundance, metabolomics based on heteronuclear NMR is limited by sensitivity. We have recently demonstrated how hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reliable wa ...

Amer Chemical Soc2016

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Robert Konrat, Jonas Milani, Pascal Miéville, Basile Vuichoud, Florian Patrick Marie Daniel De la Barre De Nanteuil, Xiao Ji, Estel Canet Martinez

Hyperpolarization is generated by dissolution dynamic nuclear polarization (d-DNP) using a polymer-based polarizing agent dubbed FLAP (filterable labeled agents for polarization). It consists of a thermo-responsive poly(N-isopropylacrylamide), also known a ...

Wiley-V C H Verlag Gmbh2016

Microwave-gated dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Xiao Ji, Arthur César Pinon, David Lyndon Emsley, Mathieu Baudin

Dissolution dynamic nuclear polarization (D-DNP) has become a method of choice to enhance signals in nuclear magnetic resonance (NMR). Recently, we have proposed to combine cross-polarization (CP) with D-DNP to provide high polarization P(C-13) in short bu ...

Royal Society of Chemistry2016

Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Daniele Mammoli, Xiao Ji

Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) offers a way of enhancing NMR signals by up to five orders of magnitude in metabolites and other small molecules. Nevertheless, the lifetime of hyperpolarization is inexorably limited, a ...

Wiley-Blackwell2014