Publications de Jean-Baptiste Mignardot

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Tomislav Milekovic, Léonie Asboth, Camille Georgette Marie Le Goff-Mignardot, Giuseppe Schiavone, Elvira Pirondini, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean François Pierre Laurens, Jean-Baptiste Mignardot, Flavio Raschella, Robin Jonathan Demesmaeker, Simon Borgognon, Jocelyne Bloch, Shiqi Sun, Sergio Daniel Hernandez, Jordan Squair, Nicolò Macellari, Jimmy James Ravier, Carmina Andrea Galvez Solano, Grégory Didier Dumont

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Neural and muscular factors both contribute to plantarflexor muscle weakness in older fallers (vol 112, pg 127, 2018)

Jean-Baptiste Mignardot

PERGAMON-ELSEVIER SCIENCE LTD2019

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018

Apparatus comprising a support system for a user and its operation in a gravity-assist mode

Camille Georgette Marie Le Goff-Mignardot, Grégoire Courtine, Joachim von Zitzewitz, Jean-Baptiste Mignardot

The present application relates to devices and systems for rehabilitation of the locomotor system, for example limbs. In particular, the present application discloses an apparatus, more in particular a robotic platform capable of optimizing gravity-depende ...

2018

Neural and muscular factors both contribute to plantar-flexor muscle weakness in older fallers

Jean-Baptiste Mignardot

Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aime ...

PERGAMON-ELSEVIER SCIENCE LTD2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Camille Georgette Marie Le Goff-Mignardot, Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Andreas Rowald, Karen Minassian, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Selin Anil, Joachim von Zitzewitz, Rubia van den Brand, Marco Capogrosso, Jean-Baptiste Mignardot, Nicolas Francis Fumeaux, Jessica Lanini, Jocelyne Bloch

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Tomislav Milekovic, Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Elodie Rey, Jocelyne Bloch

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz, Rubia van den Brand, Eduardo Martin Moraud, Marco Capogrosso, Jean-Baptiste Mignardot, Nicolas Francis Fumeaux, Fabien Bertrand Paul Wagner, Jocelyne Bloch

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Gait disturbances as specific predictive markers of the first fall onset in elderly people: a two-year prospective observational study

Jean-Baptiste Mignardot

Falls are common in the elderly, and potentially result in injury and disability. Thus, preventing falls as soon as possible in older adults is a public health priority, yet there is no specific marker that is predictive of the first fall onset. We hypothe ...

Frontiers Research Foundation2014

Effects of total sleep deprivation on the perception of action capabilities

Jean-Baptiste Mignardot

Changes in a subject's state have been shown to modulate the perceptual update of his or her action capabilities. In parallel, sleep deprivation impairs in cognitive functions. It involves common neural structures that support the perception of successfull ...

Springer2014