Publications de Estel Canet Martinez

Study of fast exchanging processes by NMR Spectroscopy

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and informative methods to probe molecular dynamics. Specifically, chemical exchange is an important phenomenon and one of the earliest and most vigorously investigated in NMR spectr ...

EPFL2017

Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization

Geoffrey Bodenhausen, Sami Jannin, Jonas Milani, Sina Marhabaie, Daniel Abergel, Estel Canet Martinez, Matthias Weller

We present novel means to hyperpolarize deuterium nuclei in (CD2)-C-13 groups at cryogenic temperatures. The method is based on cross-polarization from H-1 to C-13 and does not require any radio-frequency fields applied to the deuterium nuclei. After rapid ...

Amer Inst Physics2016

Ligand-Protein Affinity Studies Using Long-Lived States of Fluorine-19 Nuclei

Geoffrey Bodenhausen, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

The lifetimes T-LLS of long-lived states or T-LLC of long-lived coherences can be used for the accurate determination of dissociation constants of weak protein ligand complexes. The remarkable contrast between signals derived from LLS or LLC in free and bo ...

American Chemical Society2016

Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Robert Konrat, Jonas Milani, Pascal Miéville, Basile Vuichoud, Florian Patrick Marie Daniel De la Barre De Nanteuil, Xiao Ji, Estel Canet Martinez

Hyperpolarization is generated by dissolution dynamic nuclear polarization (d-DNP) using a polymer-based polarizing agent dubbed FLAP (filterable labeled agents for polarization). It consists of a thermo-responsive poly(N-isopropylacrylamide), also known a ...

Wiley-V C H Verlag Gmbh2016

Kinetic isotope effects for fast deuterium and proton exchange rates

Geoffrey Bodenhausen, Daniele Mammoli, Pavel Kaderavek, Estel Canet Martinez

By monitoring the effect of deuterium decoupling on the decay of transverse N-15 magnetization in D-N-15 spin pairs during multiple-refocusing echo sequences, we have determined fast D-D exchange rates k(D) and compared them with fast H-H exchange rates k( ...

Royal Society of Chemistry2016

Collisional cross-section of water molecules in vapour studied by means of H-1 relaxation in NMR

Geoffrey Bodenhausen, Lothar Helm, Pascal Miéville, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

In gas phase, collisions that affect the rotational angular momentum lead to the return of the magnetization to its equilibrium (relaxation) in Nuclear Magnetic Resonance (NMR). To the best of our knowledge, the longitudinal relaxation rates R-1 = 1/T-1 of ...

Nature Research2016

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Nicola Salvi, Diego Carnevale, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

Para-water is an analogue of para-hydrogen, where the two proton spins are in a quantum state that is antisymmetric under permutation, also known as singlet state. The populations of the nuclear spin states in para-water are believed to have long lifetimes ...

Royal Society of Chemistry2015