Publications de Xiaokang Li | EPFL Graph Search

Molecular profiling of tumor-specific cytolytic CD4 T cells in human cancer

Hatice Altug, Xiaokang Li, Yen-Cheng Liu, Xuan Li

WILEY2022

Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray

Hatice Altug, Xiaokang Li, Yen-Cheng Liu, Eduardo Romero Arvelo, Saeid Ansaryan

Proteins secreted by cells play significant roles in mediating many physiological, developmental, and pathological processes due to their functions in intra/intercellular communication and signaling. Conventional end-point methods are insufficient for unde ...

Elsevier2022

Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

David Gfeller, Georg Alexander Rockinger, Pedro Romero, Amélie Cachot, Hatice Altug, Margaux Saillard, Xiaokang Li, George Coukos, Yen-Cheng Liu, Alexandre Harari, Alexander Mathis

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displayi ...

2021

Tumor-Specific Cytolytic Cd4 T Cells Mediate Protective Immunity Against Human Cancer

David Gfeller, Pedro Romero, Amélie Cachot, Hatice Altug, Margaux Saillard, Xiaokang Li, George Coukos, Yen-Cheng Liu, Alexandre Harari, Alexander Mathis

BMJ PUBLISHING GROUP2020

Membrane activity detection in cultured cells using phase-sensitive plasmonics

Liliane Glauser, Johannes Gräff, Xiaokang Li, Jose Vicente Sanchez Mut, Yasaman Jahani, Foziyeh Sohrabi, Ershad Mohammadi

Despite the existence of various neural recording and mapping techniques, there is an open territory for the emergence of novel techniques. The current neural imaging and recording techniques suffer from invasiveness, a time-consuming labeling process, poo ...

2020

An integrated nanoplasmonic biosensor for monitoring cytokine secretion from single cells

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, George Coukos, Maria Soler Aznar

An innovative nanoplasmonic biosensor was presented for real-time label-free monitoring of cytokine secretion at single-cell resolution. This biosensor is integrated with a uniquely designed microfluidic device that provides a microchamber for cell incubat ...

IEEE2019

Integrated Nanophotonic Biosensors for Point-of Care Diagnostics and Bioanalytical Applications

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Yasaman Jahani

In an effort to address the requirements of next-generation healthcare systems, including personalized medicine, point-of-care diagnostics, and global health surveillance, I will introduce imaging-based portable nanoplasmonic biosensors integrated with mic ...

IEEE2019

Label-free plasmonic biosensors for real-time live cell analysis

Xiaokang Li

For decades, the understanding of life has been focused on its most fundamental building blocks: molecules. Deciphering the dynamic activities of protein molecules in human cells is of vital significance for fundamental and clinical studies. The minuscule ...

EPFL2019

Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar, Aurélian Michel John-Herpin

The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity and kinetics of a T cell receptor (TCR) binding to the peptide-major ...

AMER CHEMICAL SOC2018

Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar

Single-cell analysis of cytokine secretion is essential to understand the heterogeneity of cellular functionalities and develop novel therapies for multiple diseases. Unraveling the dynamic secretion process at single-cell resolution reveals the real-time ...

2018

Towards a point-of-care nanoplasmonic biosensor for rapid and multiplexed detection of pathogenic infections

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

The implementation of multiplexed point-of-care biosensors is a top priority to address the current epidemic problems originated by widespread pathogenic infections, like those caused by viruses or bacteria. A rapid and accurate detection, identification, ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Optofluidic nanoplasmonic biosensor for label-free live cell analysis in real time

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar

Cell signaling activities play a critical role in physiological and disease processes. The analysis of the tumor microenvironment or the immune system activation is nowadays providing valuable insights towards disease understanding and novel therapies deve ...

2018

Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion

Hatice Altug, Alexander Belushkin, Filiz Yesilköy, Xiaokang Li, Maria Soler Aznar, Cenk Ibrahim Özdemir

Cell secretion dynamics plays a central role in physiological and disease processes. Due to its various temporal profiles, it is essential to implement a precise detection scheme for continuous monitoring of secretion in real time. The current fluorescent ...

Royal Society of Chemistry2017