Publications de Maria Cristina Letizia

CMOS and 3D Printing for NMR Spectroscopy at the Single Embryo Scale

Johann Michler, Giovanni Boero, Martinus Gijs, Franck Vincent, Jürgen Brugger, Nicola Harris, Enrica Montinaro, Laszlo Pethö, Beatrice Volpe, Marco Grisi, Maria Cristina Letizia

SWISS CHEMICAL SOC2019

A design of experiment approach for efficient multi-parametric drug testing using a Caenorhabditis elegans model

Martinus Gijs, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia, Giuseppe Tranchida

When studying the drug effectiveness towards a target model, one should distinguish the effects of the drug itself and of all the other factors that could influence the screening outcome. This comprehensive knowledge is crucial, especially when model organ ...

2018

3D printed microchannels for sub-nL NMR spectroscopy

Johann Michler, Giovanni Boero, Martinus Gijs, Jürgen Brugger, Enrica Montinaro, Laszlo Pethö, Marco Grisi, Maria Cristina Letizia

Nuclear magnetic resonance (NMR) experiments on subnanoliter (sub-nL) volumes are hindered by the limited sensitivity of the detector and the difficulties in positioning and holding such small samples in proximity of the detector. In this work, we report o ...

2018

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution

Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia, Vincenzo Sorrentino

2018

Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model

Maria Cristina Letizia

Caenorhabditis elegans is a performant model system for studying human biological processes and diseases and for pre-clinical phenotyping screenings of compounds. Microfluidics has been instrumental in enabling C. elegans-based drug assays, facilitating th ...

EPFL2018

A multiscale study of the role of dynamin in the regulation of glucose uptake

Martinus Gijs, Kristina Schoonjans, Johan Auwerx, Laurent Mouchiroud, Keir Joe Menzies, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where c ...

Royal Soc Chemistry2017