Publications de Pooja Jha | EPFL Graph Search

COX7A2L genetic variants determine cardiorespiratory fitness in mice and human

Johan Auwerx, Maroun Bou Sleiman, Pooja Jha, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez

Benegiamo et al. identify genetic variants of the mitochondrial supercomplex assembly factor COX7A2L in the skeletal muscle of mice and humans that promote cardiorespiratory fitness. ...

NATURE PORTFOLIO2022

The mouse metallomic landscape of aging and metabolism

Johan Auwerx, Richardus Houtkooper, Evan Graehl Williams, Pooja Jha, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne

The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, age-dep ...

Nature Research2022

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

Johan Auwerx, Evan Graehl Williams, Maroun Bou Sleiman, Pooja Jha

How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...

NATURE PORTFOLIO2021

The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Johan Auwerx, Richardus Houtkooper, Maroun Bou Sleiman, Xu Wang, Pooja Jha

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and ag ...

2020

Plasma and liver lipid species as biomarkers of fatty liver

Johan Auwerx, Pooja Jha

The invention relates to plasma or liver lipid species selected from the triacylglycerol (TAG) and cardiolipin (CL) lipid classes measured by LC-MS/MS and use thereof as diagnostic and prognostic biomarkers of fatty liver, as well as to monitor the efficac ...

2018

ERR gamma Preserves Brown Fat Innate Thermogenic Activity

Johan Auwerx, Pooja Jha

2018

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes

Johan Auwerx, Evan Graehl Williams, Maroun Bou Sleiman, Karim Laurent Gariani, Pooja Jha, Pedro Moral Quiros

2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Johan Auwerx, Pooja Jha

2018

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

Johan Auwerx, Evan Graehl Williams, Léo Aurélio Diserens, Maroun Bou Sleiman, Karim Laurent Gariani, Pooja Jha, Pedro Moral Quiros

2018

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

Ruedi Aebersold, Johan Auwerx, Evan Graehl Williams, Dongryeol Ryu, Pooja Jha, Jiayi Lan, Jun Yong Kim, Moaraj Hasan

We have used SWATH mass spectrometry to quantify 3648 proteins across 76 proteomes collected from genetically diverse BXD mouse strains in two fractions (mitochondria and total cell) from five tissues: liver, quadriceps, heart, brain, and brown adipose (BA ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2018

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

Chiara Greggio, Johan Auwerx, Carlos Canto Alvarez, Xu Wang, Pooja Jha

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiova ...

Cell Press2017

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Elena Katsyuba, Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies, Alessia Perino, Karim Laurent Gariani, Vera Monica Lemos Da Silva, Pooja Jha, Jun Yong Kim

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

Systems proteomics of liver mitochondria function

Sébastien Dubuis, Ruedi Aebersold, Johan Auwerx, Evan Graehl Williams, Tiffany Amariuta, Pooja Jha

Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS), permit reproducible large-scale protein measurements across diverse cohorts. Together with genomics, transcriptom ...

American Association for the Advancement of Science2016

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Patrick Aebischer, Maria del Carmen Sandi Perez, Elena Katsyuba, Johan Auwerx, Damien Sébastien Huzard, Norman Lionel Moullan, Pénélope Andreux, Evan Graehl Williams, Dongryeol Ryu, Laurent Mouchiroud, Giuseppe Lo Sasso, Pooja Jha

The biological effects of urolithins remain poorly characterized, despite wide-spread human exposure via the dietary consumption of their metabolic precursors, the ellagitannins, which are found in the pomegranate fruit, as well as in nuts and berries. We ...

2016