Publications de Francesca Stradolini

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Sandro Carrara, Ioulia Tzouvadaki, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Francesca Criscuolo, Simone Aiassa

The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approa ...

2020

Electrochemical detection of different p53 conformations by using nanostructured surfaces

Sandro Carrara, Francesca Stradolini, Sarah Tonello

Protein electrochemistry represents a powerful technique for investigating the function and structure of proteins. Currently available biochemical assays provide limited information related to the conformational state of proteins and high costs. This work ...

Springer Nature2019

Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery

Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Simone Aiassa

Monitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right procedure of anaesthesia. Nowadays, there are no commercial tools able to ...

IEEE2019

Highly-stable Li + ion-selective electrodes based on noble metal nanostructured layers as solid-contacts

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Stradolini, Francesca Criscuolo

Nowadays the development of stable and highly efficient Solid-Contact Ion-Selective Electrodes (SC-ISEs) attracts much attention in the research community because of the great expansion of portable analytical devices. In this work, we present highly stable ...

2018

Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Nima Aliakbarinodehi, Ioulia Tzouvadaki, Francesca Stradolini, Sattar Akbari Nakhjavani

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...

2018

Organs-on-chip monitoring: sensors and other strategies

Philippe Renaud, Sandro Carrara, Fatemeh Navaee, Francesca Stradolini, Tugba Kilic

As a paradigm shifting player of tissue engineering, organs-on-chips (OOCs) are considered to hold great potential for future “clinical trials on chip” as well as a step forward to design personalized medicine. Despite all ethical concerns raised by commun ...

2018

Long-term Monitoring of Propofol and Fouling Effect on Pencil Graphite Electrodes

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini

2018

An IoT Solution for Online Monitoring of Anesthetics in Human Serum Based on an Integrated Fluidic Bioelectronic System

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Tugba Kilic, Sofia Lydia Ntella, Nadia Tamburrano, Zijian Huang

In this paper, we present the design, the implementation and the validation of a novel Internet of Things (IoT) drug monitoring system for the online continuous and simultaneous detection of two main anesthetics, e.g., propofol and paracetamol, in undilute ...

2018

IoT for Telemedicine Practices enabled by an Android (TM) Application with Cloud System Integration

Sandro Carrara, Thiébaud Modoux, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Nadia Tamburrano

Connected medical devices are already paving the way towards the realization of Smart Hospitals where patient care is improved thanks to Internet of Things (IoT) solutions. Following this trend, in this paper we propose an IoT cloud-based network for anest ...

IEEE2018

A Flexible Front-End for Wearable Electrochemical Sensing

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Tugba Kilic, Francesca Criscuolo, Lucia Lobello

This work presents the design and the realization of a flexible front-end circuitry for electrochemical sensing with wearable devices. The hardware combines readout circuitry for amperometric and Open Circuit Potential (OCP) measurements. The sensing platf ...

IEEE2018

Fouling-resistant pencil graphite electrode

Sandro Carrara, Francesca Stradolini, Tugba Kilic

A Pencil Graphite Electrode (PGE) is herein disclosed. The electrode is characterized by a reduced content in graphite and an increased content in clay of the composite material composing it compared to the prior art PGEs. In particular, the PGE according ...

2018

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

Raspberry-Pi based system for propofol monitoring

Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Tugba Kilic

Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...

ELSEVIER SCIENCE BV2018

Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum

Giovanni Boero, Giovanni De Micheli, Irene Taurino, Francesca Stradolini, Tugba Kilic

In this work, we present a novel electrochemical cleaning procedure for long-term electrochemical monitoring of propofol by using boron-doped diamond (BDD) and pencil graphite electrode (PGE). Propofol is an anesthetic that is widely used for long-lasting ...

2018

Wearable System for Spinal Cord Injury Rehabilitation with Muscle Fatigue Feedback

Sandro Carrara, Francesca Stradolini, Danilo Demarchi, Diego Marino, Sofia Milanese

The design, realization and verification of a system for personalized rehabilitation of Spinal Cord Injury (SCI) patients are here presented. It consists of two main parts: (i) one induces in the patient the physiotherapic movement proposed by the trainer ...

IEEE2018

Live Demonstration: An IoT Cloud-Based Architecture for Anesthesia Monitoring

Sandro Carrara, Thiébaud Modoux, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Nadia Tamburrano

Medical Internet of Things (IoT) solutions are already paving the way towards the realization of Smart Hospitals. Following this trend, we propose an IoT cloud-based network for anesthesia on-line monitoring. This architecture allows the anesthesiologist t ...

IEEE2018

Generating Safety Guidance for Medical Injection with Three-Compartment Pharmacokinetics Model

Giovanni De Micheli, Francesca Stradolini, Heinz Riener, Cunxi Yu

Medical cyber-physical systems are a new trend of software controlled physical systems that are increasingly common in medical domains. With rapid developments in medical science and computer technology, safety verification and simulation becomes more chal ...

IEEE2018

Raspberry Pi Driven Flow-Injection System for Electrochemical Continuous Monitoring Platforms

Giovanni De Micheli, Federico Angiolini, Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Bruno Donato

Nowadays, there is an immense interest regarding new bio-sensing technologies, highlighting the need for effective validation of their capabilities. This necessity is more crucial when examining the proprieties of a sensor for continuous monitoring of a co ...

IEEE2017

Paradigm-Shifting Players for IoT: Smart-Watches for Intensive Care Monitoring

Giovanni De Micheli, Sandro Carrara, Eleonora Lavalle, Francesca Stradolini, Danilo Demarchi

Wearable devices, e.g. smart-watches, are gaining popularity in many fields and in wellness monitoring too. In this paper we propose an IoT application to alert the medical doctor assigned to a critical unit by using a smart-watch. The wearable device impr ...

2016

In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

Catherine Dehollain, Giovanni De Micheli, Andrea Cavallini, Sandro Carrara, Enver Gürhan Kilinç, Camilla Baj-Rossi, Francesca Stradolini

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in ...

Ieee-Inst Electrical Electronics Engineers Inc2016