Publications de Gael Luis Boivin

Trajectories of macrophage ontogeny and reprogramming in cancer

Michele De Palma, Céline Wyser Rmili, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Nahal Mansouri

Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

2025

Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy

Caroline Anne-Lyse Contat, Etienne Meylan, Gael Luis Boivin, Pierre-Benoit Bernard Ancey

The anti-Ly6G antibody is used to deplete Ly6G(pos) neutrophils and study their role in diverse pathologies. However, depletion is never absolute, as Ly6G(low) neutrophils resistant to depletion rapidly emerge. Studying the functionality of these residual ...

2021

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Nadine Fournier, Caroline Anne-Lyse Contat, Etienne Meylan, Justine Pascual, Gael Luis Boivin, Pierre-Benoit Bernard Ancey, Silvia Sabatino

Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In cancer, pro- or antitumor properties have been attributed to tumor-associated neutrophils (TAN). Here, focusing on TAN accumulation within lung tumors, we id ...

AMER ASSOC CANCER RESEARCH2021

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Ioanna Keklikoglou, Nadine Fournier, Sina Nassiri, Etienne Meylan, Michele De Palma, Ece Kadioglu, Chiara Cianciaruso, Bruno Torchia, Gael Luis Boivin, Alan Nicolas Thierry Guichard, Amaia Martinez Usatorre

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Durable and controlled depletion of neutrophils in mice

Caroline Anne-Lyse Contat, Etienne Meylan, Jessica Christine Vazquez, Justine Pascual, Julien Robert Rémi Faget, Gael Luis Boivin, Pierre-Benoit Bernard Ancey, Aspasia Gkasti

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

Nature Research2020

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

Etienne Meylan, Julien Robert Rémi Faget, Gael Luis Boivin

2018

Neutrophils and Snail orchestrate the establishment of a protumor microenvironment in lung adenocarcinoma

Nicolas Jean Philippe Guex, Miguel Garcia, Nadine Fournier, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Gael Luis Boivin, Ioannis Xenarios, Inti Zlobec

AMER ASSOC CANCER RESEARCH2018

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Miguel Garcia, Nadine Fournier, Etienne Meylan, Loïc Steiner, Alessandra Piersigilli, Julien Robert Rémi Faget, Svenja Johanna Groeneveld, Gael Luis Boivin, Ioannis Xenarios, Inti Zlobec

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

François Bochud, Raphaël Doenlen, Gael Luis Boivin

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate ...

Elsevier Ireland Ltd2017