Publications de Fabien Bertrand Paul Wagner

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Léonie Asboth, Salif Axel Komi, Grégoire Courtine, Miroslav Caban, Nicolas Hankov, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Jocelyne Bloch, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Cathal John Harte

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

System for control of spasticity

Salif Axel Komi, Grégoire Courtine, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Karen Minassian, Jocelyne Bloch

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Léonie Asboth, Nawal Noëlle Kinany, Salif Axel Komi, Silvestro Micera, Grégoire Courtine, Miroslav Caban, Quentin Barraud, Marco Capogrosso, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Nathan Antoine Greiner, Jocelyne Bloch, Sergio Daniel Hernandez, Laura Ann McCracken, Henri Charles Alexandre Lorach, Edeny Baaklini, Jimmy James Ravier, Carmina Andrea Galvez Solano

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Léonie Asboth, Salif Axel Komi, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Laetitia Danielle Philippine Baud, Katia Galan, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Kyungjin Kim, Thomas Haynes Hutson, Steven Lee Ceto

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Giuseppe Schiavone, Ludovic Serex, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Fabien Bertrand Paul Wagner

Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized elec ...

2021

System for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Jérôme Gandar, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Salif Axel Komi, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Eduardo Martin Moraud, Marco Capogrosso, Mark Andrew Anderson, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Ileana Ozana Jelescu, Andreas Rowald, Newton Cho, Jocelyne Bloch, Claudia Kathe, Nicholas David James, Jordan Squair, Laura Ann McCracken, Matthieu Pierre Gautier, Loïs Thomas Romain Mahe, Jimmy James Ravier

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a stimulation related basic data storage module (28) for storing the stimulation related basic data, - a stimulation rel ...

2019

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising: - first data input module (26) for stimulation related basic data, - a stimulation related basic data storage module (28) ...

2019

System for planning and/or providing neuromodulation, especially neurostimulation

Vincent Delattre, Grégoire Courtine, Miroslav Caban, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a neurostimulator (24) comprising a least one electrode (22), - functional mapping module (38) configured and arranged such t ...

2019

A system for planning and/or providing neurostimulation for a patient

Vincent Delattre, Tomislav Milekovic, Grégoire Courtine, Marco Capogrosso, Flavio Raschella, Fabien Bertrand Paul Wagner

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

IEEE2018

Two-phase calibration of a neuroprosthetic system

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Fabien Bertrand Paul Wagner

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Camille Georgette Marie Le Goff-Mignardot, Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Andreas Rowald, Karen Minassian, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Tomislav Milekovic, Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Elodie Rey, Jocelyne Bloch

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz, Rubia van den Brand, Eduardo Martin Moraud, Marco Capogrosso, Jean-Baptiste Mignardot, Nicolas Francis Fumeaux, Fabien Bertrand Paul Wagner, Jocelyne Bloch

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Detection of Optogenetic Stimulation in Somatosensory Cortex by Non-Human Primates - Towards Artificial Tactile Sensation

David Allenson Borton, Fabien Bertrand Paul Wagner

Neuroprosthesis research aims to enable communication between the brain and external assistive devices while restoring lost functionality such as occurs from stroke, spinal cord injury or neurodegenerative diseases. In future closed-loop sensorimotor prost ...

Public Library of Science2014