Publications de Ece Yildiz | EPFL Graph Search

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Ece Yildiz, Hadrien Charles Edouard Demagny, Nadia Bresciani, Yu Sun, Antoine Jalil

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam, Antoine Jalil

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

Ece Yildiz

The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...

EPFL2022

Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes

Ece Yildiz

In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study invest ...

WILEY-V C H VERLAG GMBH2022

Mechano-modulatory synthetic niches for liver organoid derivation

Matthias Lütolf, Kristina Schoonjans, Saba Rezakhani, Ece Yildiz, Giovanni Sorrentino

The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling. The use of three-dimensional (3D) cultures based on ill-defined and potentially immunog ...

Nature Publishing Group2020

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Maroun Bou Sleiman, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020

Three dimensional models of tissue fibrosis

Matthias Lütolf, Kristina Schoonjans, Saba Rezakhani, Ece Yildiz, Giovanni Sorrentino

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020