Publications de Polina Shkorbatova

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Silvestro Micera, Grégoire Courtine, Marco Bonizzato, Natalia Pavlova, Galyna Pidpruzhnykova, Polina Shkorbatova

The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...

Nature Publishing Group2018

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Bernard Schneider, Léonie Asboth, Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Selin Anil, Quentin Barraud, Cristina Martinez Gonzalez, Julie Kreider, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Galyna Pidpruzhnykova, Elodie Rey, Polina Shkorbatova

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Sophie Marie Marthe Wurth, Jérôme Gandar, Nawal Noëlle Kinany, Silvestro Micera, Grégoire Courtine, Stanisa Raspopovic, Quentin Barraud, Alessandra Piersigilli, Marco Capogrosso, Natalia Pavlova, Jacopo Rigosa, Polina Shkorbatova

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Elsevier Sci Ltd2017