Publications de Aleksey Yevtodiyenko

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD plus metabolism

Elena Goun, Arkadiy Bazhin, Pavlo Khodakivskyi, Georgy Mikhaylov, Aleksey Yevtodiyenko, Tamara Maric

Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders. Despite its wide commercial availability a ...

ELSEVIER ADVANCED TECHNOLOGY2023

Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans

Elena Goun, Arkadiy Bazhin, Pavlo Khodakivskyi, Aleksey Yevtodiyenko

The microbiome-produced enzyme bile salt hydrolase (BSH) plays a central role in human health, but its function remains unclear due to the lack of suitable methods for measuring its activity. Here, we have developed a novel optical tool based on ultrasensi ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Bioluminescent compositions and uses thereof

Elena Goun, Hacer Karatas, Pavlo Khodakivskyi, Aleksey Yevtodiyenko

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bon ...

2021

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals

Aurélien Godinat, Elena Goun, Arkadiy Bazhin, Ghyslain Martial Alain Budin, Pavlo Khodakivskyi, Aleksey Yevtodiyenko, Tamara Maric

Bioluminescent imaging (BLI) is one of the most powerful and widely used preclinical imaging modalities. However, the current technology relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited ...

Nature Research2021

Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo

Elena Goun, Hacer Karatas, Pier Luca D'Alessandro, Aleksey Yevtodiyenko, Tamara Maric

Peptides constitute an important class of drugs for the treatment of multiple metabolic, ontological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development. Howeve ...

AMER CHEMICAL SOC2019

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Elena Goun, Arkadiy Bazhin, Riccardo Sinisi, Pavlo Khodakivskyi, Georgy Mikhaylov, Aleksey Yevtodiyenko, Tamara Maric

Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...

NATURE PUBLISHING GROUP2019

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

Aurélien Godinat, Elena Goun, Aleksey Yevtodiyenko

A system for monitoring biological processes in vivo is provided. The system comprises an implantable luciferase biosensor comprising luciferase in a biocompatible matrix and a caged luciferin probe. The caged luciferin probe can be administered to a livin ...

2018