Publications de Mahmut Selman Sakar

Technology Roadmap of Micro/Nanorobots

American Chemical Society (ACS)2025

An acoustic levitation platform for high-content histological analysis of 3D tissue culture

Emilie Vuille-Dit-Bille, Mahmut Selman Sakar

Miniaturized three-dimensional (3D) cell culture systems, in particular organoids and spheroids, hold great potential for studying morphogenesis, disease modeling, and drug discovery. However, sub-cellular resolution 3D imaging of these biological samples ...

Royal Society of Chemistry (RSC)2025

A Flat Tendon-Driven Continuum Microrobot for Brain Interventions

Lucio Feo Pancaldi-Giubbini, Lorenzo Francesco John Noseda, Mahmut Selman Sakar

Navigating biomedical instruments inside the brain remains challenging and high-risk. The delicate nature of the tissues involved requires the development of cutting-edge robotic technologies to enhance precision and safety. In response to these demands, t ...

Institute of Electrical and Electronics Engineers Inc.2024

Precise tactile stimulation of worker ants by a robotic manipulator reveals that individual responses are density‐ and context‐dependent

Laurent Keller, Alexandre Tuleu, Matthias Rüegg, Mahmut Selman Sakar

2024

3D printed large amplitude torsional microactuators powered by ultrasound

Mehdi Ali Gadiri, Mahmut Selman Sakar, Amit Yedidia Dolev, Junsun Hwang

Here, we introduce a design, fabrication, and control methodology for large amplitude torsional microactuators powered by ultrasound. The microactuators are 3D printed from two polymers with drastically different elastic moduli as a monolithic compliant me ...

2024

Modeling the mechanosensitive collective migration of cells on the surface and the interior of morphing soft tissues

Mahmut Selman Sakar, Jaemin Kim

Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic development, wound healing, tissue morphogenesis, and regeneration. Even though the distinct response of c ...

Springer Science and Business Media LLC2024

Targeted worker removal reveals a lack of flexibility in brood transport specialisation with no compensatory gain in efficiency

Laurent Keller, Mahmut Selman Sakar, Fazil Emre Uslu

Division of labour is widely thought to increase the task efficiency of eusocial insects. Workers can switch their task to compensate for sudden changes in demand, providing flexible task allocation. In combination with automated tracking technology, we de ...

Nature Research2024

A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

Mahmut Selman Sakar, Ece Özelçi, Andrew Charles Oates, Laurel Ann Rohde, Erfan Etesami

Microsurgical manipulations are key experimental techniques in life science research, particularly in embryology. These techniques are most often performed manually by highly skilled scientists, posing limitations on speed, precision, and reproducibility. ...

2024

Small-scale robotic devices for medical interventions in the brain

Lorenzo Francesco John Noseda, Mahmut Selman Sakar

This article summarizes the recent advancements in the design, fabrication, and control of microrobotic devices for the diagnosis and treatment of brain disorders. With a focus on diverse actuation methods, we discuss how advancements in materials science ...

2024

A graduate laboratory experiment to study the dynamics of an acoustically levitated particle

Lorenzo Francesco John Noseda, Mahmut Selman Sakar, Amit Yedidia Dolev, Bora Yalcin

The comprehension of physical wave phenomena is imperative for students in the fields of engineering and basic sciences. Laboratory experiments that involve generation of acoustic waves can be used to explain advanced nonlinear wave phenomena. Acoustic lev ...

2023

3D Printed Acoustically Programmable Soft Microactuators

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

The concept of creating all-mechanical soft microrobotic systems has great potential to address outstanding challenges in biomedical applications, and introduce more sustainable and multifunctional products. To this end, magnetic fields and light have been ...

2023

Acoustic Levitation apparatus (Robotics Practicals)

Lorenzo Francesco John Noseda, Mahmut Selman Sakar, Amit Yedidia Dolev, Bora Yalcin

The following data contain the information and files, which are required to recreate and build the experimental setup that is described in the Laboratory manual. Further details can be found in the associated publication “A graduate laboratory experiment t ...

Zenodo2023

Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Mahmut Selman Sakar, Murat Kaynak, Zhangjun Huang, Haiyan Jia

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. He ...

2023

A model for mechanosensitive cell migration in dynamically morphing soft tissues

Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Jaemin Kim

2023

Dynamics of entrapped microbubbles with multiple openings

Mahmut Selman Sakar, Murat Kaynak, Amit Yedidia Dolev

Microbubbles excited by acoustic fields inside water oscillate, and generate acoustic radiation forces and drag-induced acoustic streaming. These forces can be harnessed in various biomedical applications such as targeted drug delivery and on-chip biomanip ...

2022

Locomotion of Sensor‐Integrated Soft Robotic Devices Inside Sub‐Millimeter Arteries with Impaired Flow Conditions

Lucio Feo Pancaldi-Giubbini, Lorenzo Francesco John Noseda, Diego Ghezzi, Mahmut Selman Sakar, Adele Fanelli, Amit Yedidia Dolev

One of the grand challenges in interventional cardiology and neuroradiology is to minimize the operation time and risk of damage during catheterization. These two factors drastically increase if the target location resides in small and tortuous vessels. Fl ...

Wiley2022

Actuated 3D microgels for single cell mechanobiology

Christina Myra Tringides, Mahmut Selman Sakar, Ece Özelçi, Berna Ayse Özkale Edelmann

We present a new cell culture technology for large-scale mechanobiology studies capable of generating and applying optically controlled uniform compression on single cells in 3D. Mesenchymal stem cells (MSCs) are individually encapsulated inside an optical ...

ROYAL SOC CHEMISTRY2022

Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila

Pavan P Ramdya, Mahmut Selman Sakar, Chin-Lin Chen, Murat Kaynak, Semih Günel, Victor Lobato Rios, Laura Joan Hermans, Florian Aymanns, Jonas Friedrich Braun

The dynamics and connectivity of neural circuits continuously change on timescales ranging from milliseconds to an animal's lifetime. Therefore, to understand biological networks, minimally invasive methods are required to repeatedly record them in behavin ...

Nature Research2022

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Matthias Rüegg, Mahmut Selman Sakar, Erik Mailand, Ece Özelçi, Andrew Charles Oates

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

Nature Research2022

Actuated 3D microgels for single cell mechanobiology (vol 22, pg 1962, 2022)

Christina Myra Tringides, Mahmut Selman Sakar, Ece Özelçi, Berna Ayse Özkale Edelmann

ROYAL SOC CHEMISTRY2022