Publications de Audrey Geneviève Chuat

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

Béatrice Kunz, Olivier Burri, Françoise Gisou van der Goot Grunberg, Nathalie Brandenberg, Julien Léonard Duc, Romain Guiet, Audrey Geneviève Chuat, Lucie Josepha Marie Bracq

Patients with the rare genetic disorder Hyaline Fibromatosis Syndrome (HFS) often succumb before 18 months of age due to severe diarrhea. As HFS is caused by loss-of-function mutations in the gene encoding capillary morphogenesis gene 2 (CMG2), these sympt ...

Springer Science and Business Media LLC2025

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

Béatrice Kunz, Didier Trono, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Audrey Geneviève Chuat, Francisco De Magalhães Sarmento R De Mesquita, Lucie Josepha Marie Bracq, Joana Carlevaro Fita, Nattawadee Panyain

SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observati ...

Nature Research2023

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Oksana Andrei Sergeeva, Audrey Geneviève Chuat, Muhammad Umair Anwar, Giovanni D'Angelo, Laura Capolupo, Francisco De Magalhães Sarmento R De Mesquita, Triana Amen

To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

Cell Press - Elsevier2022

Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine

Alexis Rapin, Luc Xavier Marie Lebon, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Audrey Geneviève Chuat

Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access dif ...

2020