Publications de Goran Lovric | EPFL Graph Search

Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based mu CT-A comparison with histology

Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SR mu CT) has become a tool for extending the imaging of two-dimensional thi ...

PUBLIC LIBRARY SCIENCE2022

Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung

Anders Larsson, Marco Stampanoni, Goran Lovric

In this article, we present an X-ray tomographic imaging method that is well suited for pulmonary disease studies in animal models to resolve the full pathway from gas intake to gas exchange. Current state-of-the-art synchrotron-based tomographic phase-con ...

SPRINGER2021

Imaging atelectrauma in Ventilator-Induced Lung Injury using 4D X-ray microscopy

Anders Larsson, Goran Lovric

Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, the mechanisms leading to VILI at the microscopic scale remain poorly understood. Here we investigated the within-tidal dynamics of cyclic recru ...

NATURE RESEARCH2021

Simultaneous Reciprocal and Real Space X-Ray Imaging of Time-Evolving Systems

Marco Stampanoni, Goran Lovric

Imaging the (sub)micron scale over large areas with high temporal resolution becomes increasingly necessary for the development and investigation of novel materials under realistic operation conditions. Small angle x-ray scattering imaging methods provide ...

American Physical Society (APS)2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

Goran Lovric

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodel ...

AMER PHYSIOLOGICAL SOC2021

Sub-trabecular strain evolution in human trabecular bone

Alessandra Patera, Goran Lovric

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

NATURE RESEARCH2020

Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition

Goran Lovric

Dual contrast micro computed tomography (CT) shows potential for detecting articular cartilage degeneration. However, the performance of conventional CT systems is limited by beam hardening, low image resolution (full-body CT), and long acquisition times ( ...

2020

Stomatal closure prevents the drop in soil water potential around roots

Goran Lovric

WILEY2020

Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection

Nikolaos Stergiopoulos, Bram Trachet, Lydia Aslanidou, Goran Lovric

Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE-/- mice have been widely used to study aortic aneurysm and dissection, early morphofunctiona ...

KARGER2020

Synchrotron-based phase-contrast micro-CT as a tool for understanding pulmonary vascular pathobiology and the 3-D microanatomy of alveolar capillary dysplasia

Goran Lovric

This study aimed to explore the value of synchrotron-based phase-contrast microcomputed tomography (micro-CT) in pulmonary vascular pathobiology. The microanatomy of the lung is complex with intricate branching patterns. Tissue sections are therefore diffi ...

AMER PHYSIOLOGICAL SOC2020

Triple Contrast CT Method Enables Simultaneous Evaluation of Articular Cartilage Composition and Segmentation

Goran Lovric

Early degenerative changes of articular cartilage are detected using contrast-enhanced computed tomography (CT) with a cationic contrast agent (CA). However, cationic CA diffusion into degenerated cartilage decreases with proteoglycan depletion and increas ...

2020

Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet, Lydia Aslanidou, Mauro Ferraro, Goran Lovric

Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and ...

2019

Synchrotron-based visualization and segmentation of elastic lamellae in the mouse carotid artery during quasi-static pressure inflation

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet, Lydia Aslanidou, Mauro Ferraro, Goran Lovric

2019

Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation?

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet, Lydia Aslanidou, Mauro Ferraro, Goran Lovric

Synchrotron-based x-ray phase-contrast imaging allows for detailed 3D insight into the microstructure of soft tissue and is increasingly used to improve our understanding of mouse models of cardiovascular disease. Two techniques dominate the field: grating ...

2019

Diffractive small angle X-ray scattering imaging for anisotropic structures

Marco Stampanoni, Goran Lovric

Insights into the micro- and nano-architecture of materials is crucial for understanding and predicting their macroscopic behaviour. In particular, for emerging applications such as meta-materials, the micrometer scale becomes highly relevant. The micro-ar ...

Nature Research2019

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Goran Lovric

Early diagnosis of acute cartilage injuries enables monitoring of disease progression and improved treatment option planning to prevent post-traumatic osteoarthritis. In contrast-enhanced computed tomography (CECT), the changes in cationic agent diffusion ...

Nature Research2019

A new bioinspired method for pressure and flow sensing based on the underwater air-retaining surface of the backswimmer Notonecta

Goran Lovric

In technical systems, static pressure and pressure changes are usually measured with piezoelectric materials or solid membranes. In this paper, we suggest a new biomimetic principle based on thin air layers that can be used to measure underwater pressure c ...

2018

Mapping cardiac-induced lung motion using high-resolution time-resolved phase-contrast synchrotron computed tomography

Anders Larsson, Goran Lovric

EUROPEAN RESPIRATORY SOC JOURNALS LTD2018

Automated computer-assisted quantitative analysis of intact murine lungs at the alveolar scale

Marco Stampanoni, Goran Lovric

Using state-of-the-art X-ray tomographic microscopy we can image lung tissue in three dimensions in intact animals down to a micrometer precision. The structural complexity and hierarchical branching scheme of the lung at this level of details, however, re ...

Public Library of Science2017

Tomographic in vivo microscopy for the study of lung physiology at the alveolar level

Marco Stampanoni, Goran Lovric

Lungs represent the essential part of the mammalian respiratory system, which is reflected in the fact that lung failure still is one of the leading causes of morbidity and mortality worldwide. Establishing the connection between macroscopic observations o ...

Nature Research2017