Publications de Alice Marra | EPFL Graph Search

The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship between Drosophila melanogaster and Spiroplasma poulsonii

Bruno Lemaitre, Florent François Masson, Alice Marra

Iron is involved in numerous biological processes in both prokaryotes and eukaryotes and is therefore subject to a tug-of-war between host and microbes upon pathogenic infections. In the fruit fly Drosophila melanogaster, the iron transporter Transferrin 1 ...

Oxford University Press (OUP)2021

The role of immune effectors in controlling Drosophila-microbes interactions

Alice Marra

All live beings are in constant interaction with microorganisms that may be beneficial, deleterious or commensal. Insects in particular live in close contact with microorganisms. This is especially true for species, like the fruit fly Drosophila melanogast ...

EPFL2021

Dual proteomics of Drosophila melanogaster hemolymph infected with the heritable endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Fanny Schüpfer, Samuel Rommelaere, Florent François Masson, Alice Marra

Insects are frequently infected with heritable bacterial endosymbionts. Endosymbionts have a dramatic impact on their host physiology and evolution. Their tissue distribution is variable with some species being housed intracellularly, some extracellularly ...

2021

The Drosophila Baramicin polypeptide gene protects against fungal infection

Bruno Lemaitre, Igor Iatsenko, Alice Marra, Mark Austin Hanson

The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of effector peptides that are secreted into the haemolymph. Technical difficulties prevented the investigation of these short effector genes until the recent advent of ...

2021

Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance

Bruno Lemaitre, Alice Marra, Mark Austin Hanson

The gut microbiota affects the physiology and metabolism of animals and its alteration can lead to diseases such as gut dysplasia or metabolic disorders. Several reports have shown that the immune system plays an important role in shaping both bacterial co ...

AMER SOC MICROBIOLOGY2021

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Jean Philippe Boquete, Bruno Lemaitre, Jasquelin Peña, Igor Iatsenko, Alice Marra

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

National Academy of Sciences2020