Publications de Li Tang | EPFL Graph Search

Mimicking the TCR immune synapse for improved CAR-T cell function

SPRINGERNATURE2025

A new paradigm for cancer immunotherapy: Orchestrating type 1 and type 2 immunity for curative response

JOHN WILEY & SONS LTD2025

Metabolic immunoengineering approaches to enhance CD8+ T cell-based cancer immunotherapy

© 2024 The AuthorsMany cancer immunotherapies rely on robust CD8+ T cells capable of eliminating cancer cells and establishing long-term tumor control. Recent insights into immunometabolism highlight the importance of nutrients and metabolites in T cell ac ...

2024

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

Mei-Wen Peng, Li Tang, Yugang Guo, Yang Zhao, Bing Feng, Lucia Bonati, Rongrong Li

Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon1,2. A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1 ...

2024

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Yuqing Xie, Li Tang, Yugang Guo, Yang Zhao, Xiaomeng Hu, Bing Feng

The success of chimeric antigen receptor (CAR) T cell therapy in treating several hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of T cell exhaustion and eventually dysfunction. To counter T cell dysfunction in ...

Nature Portfolio2024

Delivery approaches of immunomodulatory nucleic acids for cancer therapy

Li Tang, Xiaomeng Hu

Messenger RNA (mRNA) vaccines have made remarkable public health contributions during the pandemic and initiated a new era for nucleic acid–based therapeutics. With the unique strength of nucleic acids, including not only mRNA but also DNA, microRNA, small ...

2024

Il-10 Expressing Cd19 Car-t Cells Induce Complete Remission and Improve Long-term Protection in Relapsed or Refractory B-cell Hematological Malignancies

Li Tang

2024

Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission

Li Tang, Bing Feng

Despite a high response rate in chimeric antigen receptor (CAR) T cell therapy for acute lymphocytic leukaemia (ALL)1–3, approximately 50% of patients relapse within the first year4–6, representing an urgent question to address in the next stage of cellula ...

2024

Harboring CAR-T cells using an injectable scaffold to treat solid tumors

Li Tang

Oxford Univ Press2024

Il-21 fusion proteins useful as enhancers of anti-cancer immunotherapies

Li Tang, Yugang Guo

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades. ...

2024

A redox-responsive prodrug for tumor-targeted glutamine restriction

Xile Hu, Daniel Ortiz Trujillo, Li Tang, Céline Jasmin Prange, Bing Feng

Modulating the metabolism of cancer cells, immune cells, or both is a promising strategy to potentiate cancer immunotherapy in the nutrient-competitive tumor microenvironment. Glutamine has emerged as an ideal target as cancer cells highly rely on glutamin ...

Elsevier2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Armand Kurum, Francesco Stellacci, Quy Ong Khac, Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Li Tang, Lixia Wei, Yong Zhu, Francesca Olgiati

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Li Tang

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

Nature Portfolio2024

6-diazo-5-oxo-l-norleucine prodrugs

Xile Hu, Li Tang, Céline Jasmin Prange

The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

2024

Evidence and therapeutic implications of biomechanically regulated immunosurveillance in cancer and other diseases

Li Tang, Lucia Bonati

Disease progression is usually accompanied by changes in the biochemical composition of cells and tissues and their biophysical properties. For instance, hallmarks of cancer include the stiffening of tissues caused by extracellular matrix remodelling and t ...

Nature Portfolio2024

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Sandrine Madeleine Suzanne Georgeon, Anthony Marchand, Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Li Tang, Sailan Shui, Stéphane Rosset, Lucia Bonati, Leo Scheller

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

2023

Highly effective adoptive t cell therapy

Li Tang, Yugang Guo, Bing Feng

The present invention relates generally to the field of anti-cancer therapy and autoimmune therapy, in particular to the use of adoptive T cell transfer therapy. More specifically, the present invention relates to compositions, pharmaceutical compositions ...

2023

Smart chemistry for traceless release of anticancer therapeutics

Xile Hu, Li Tang, Céline Jasmin Prange

In the design of delivery strategies for anticancer therapeutics, the controlled release of intact cargo at the destined tumor and metastasis locations is of particular importance. To this end, stimuli-responsive chemical linkers have been extensively inve ...

Elsevier Sci Ltd2023

Single-Cell Multi-Omics Reveals Type-2 Functionality in Maintaining CAR T Cell Longevity Associated with 8-Year Leukemia Remission

Li Tang, Bing Feng

Amer Soc Hematology2023

Il-10 expressing cells for enhanced cancer immunotherapies

Li Tang, Yugang Guo, Yang Zhao

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of adoptive T cell transfer therapy for treating cancer, in particular sold tumors. More specifically, the present invention relates to immune cells compr ...

2023