Publications de Linlin Cao | EPFL Graph Search

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Nadine Fournier, Florence Armand, Romain Hamelin, Linlin Cao, Maria Pavlou

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Linlin Cao

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...

EPFL2023

A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

Linlin Cao

The activation of memory T cells is a very rapid and concerted cellular response that requires coordination between cellular processes in different compartments and on different time scales. In this study, we use ribosome profiling and deep RNA sequencing ...

American Association of Immunologists ; Oxford University Press2022

NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy

Linlin Cao

Inhibition of the eIF4A RNA helicase with silvestrol and related compounds is emerging as a powerful anti-cancer strategy. We find that a synthetic silvestrol analogue (CR-1-31 B) has nanomolar activity across many cancer cell lines. It is especially activ ...

2021

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Rajwinder Lehal, Ute Koch, Nadine Fournier, Linlin Cao, Michele Vigolo, Jelena Zaric

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020

Measurements of isospin asymmetry and difference of direct CP asymmetries in inclusive B -> X-s gamma decays

Olivier Schneider, Sun Hee Kim, Steve Michel Berger, Tagir Aushev, Mingkui Wang, Chao Wang, Yong Chan Choi, Arnaud Michel Gelb, Kyung Taek Cho, Jun Yong Kim, Linlin Cao, Carsten Hao Ye Chong, Tara Nanut, Donghyun Kim, Martin Lubej, Chang-Hyun Park, Yifei Guan, Lei Li, Ji Hyun Kim, Yiming Li

We report measurements of isospin asymmetry Delta(0-) and difference of direct CP asymmetries Delta A(CP) between charged and neutral B -> X-s gamma decays. This analysis is based on the data sample containing 772 x 10(6)B (B) over bar pairs that was colle ...

American Physical Society2019

Search for the B -> Y(4260)K, Y(4260) -> J/psi pi(+)pi(-) decays

Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Yong Chan Choi, Kyung Taek Cho, Jun Yong Kim, Mithilesh Nayak, Linlin Cao, Carsten Hao Ye Chong, Donghyun Kim, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

We report the results of a search for the B -> Y(4260)K, Y(4260) -> J/psi pi(+)pi thorn p-decays. This study is based on a data sample corresponding to an integrated luminosity of 711 fb(-1), collected at the Upsilon(4S) resonance with the Belle detector a ...

American Physical Society2019

Search for a Light CP-odd Higgs Boson and Low-Mass Dark Matter at the Belle Experiment

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Chao Wang, Hiroyasu Yamamoto, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Ke Huang, Gaétan Charles Antoine Giriat, Jun Yong Kim, Mithilesh Nayak, Linlin Cao, Jiayun Shen, Tara Nanut, Donghyun Kim, Martin Lubej, Chang-Hyun Park, Lei Li, Ji Hyun Kim, Yiming Li

We report on the first Belle search for a light CP-odd Higgs boson, A(0), that decays into low mass dark matter, chi, in final states with a single photon and missing energy. We search for events produced via the dipion transition (sic)(2S) -> (sic)(1S)pi( ...

2019

Search for the rare decay of B+ -> l(+)nu e gamma with improved hadronic tagging

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Hiroyasu Yamamoto, Taoufiq Harach, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Mia Primorac, Arnaud Michel Gelb, Tao Yang, Gaétan Charles Antoine Giriat, Mithilesh Nayak, Linlin Cao, Jiayun Shen, Donghyun Kim, Martin Lubej, Yiming Li, Xiao Wang

We present the result of the search for the rare B meson decay of B+ -> l(+)nu e gamma with l = e, mu. For the search the full data set recorded by the Belle experiment of 711 fb(-1) integrated luminosity near the Upsilon(4S) resonance is used. Signal cand ...

American Physical Society2018

Observation of e(+) e(-) -> gamma chi(c1) and search for e(+) e(-) -> gamma chi(c0), gamma chi(c2), and gamma eta(c) at root s near 10.6 GeV at Belle

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Hiroyasu Yamamoto, Timothy Chi Hin Liew, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Tao Yang, Gaétan Charles Antoine Giriat, Jun Yong Kim, Linlin Cao, Jiayun Shen, Donghyun Kim, Martin Lubej, Chang-Hyun Park, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

Using data samples of 89.5 fb(-1), 711.0 fb(-1), and 121.4 fb(-1) collected with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider at center-of-mass energies 10.52, 10.58, and 10.867 GeV, respectively, we study the exclusive reactions e(+) ...

American Physical Society2018

Evidence of a structure in (K)over-bar(0)Lambda(+)(c) consistent with a charged Xi(c)(2930)(+), and updated measurement of (B)over-bar(0) -> (K)over-bar(0)Lambda(+)(c) (Lambda)over-bar(c)(-) at Belle

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Gaétan Charles Antoine Giriat, Jun Yong Kim, Linlin Cao, Jiayun Shen, Tara Nanut, Donghyun Kim, Chang-Hyun Park, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

We report evidence for the charged charmed-strange baryon Xi(c)(2930)(+) with a signal significance of 3.9 sigma with systematic errors included. The charged Xi(c)(2930)(+) is found in its decay to K-S(0)Lambda(+)(c) in the substructure of (B) over bar (0) ...

SPRINGER2018

Observation of gamma(2S) -> gamma eta(b)(1S) Decay

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Chao Wang, Yong Chan Choi, Alexandra Bondarenko, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Gaétan Charles Antoine Giriat, Jun Yong Kim, Linlin Cao, Jiayun Shen, Tara Nanut, Donghyun Kim, Martin Lubej, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

We report the observation of gamma(2S) -> gamma eta(b)(1S) based on an analysis of the inclusive photon spectrum of 24.7 fb(-1) of e(+)e(-) collisions at the gamma(2s) center-of-mass energy collected with the Belle detector at the KEKB asymmetric-energy e( ...

2018

Measurement of the branching fraction and time-dependent CP asymmetry for B-0 -> J/psi pi(0) decays

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Taoufiq Harach, Yong Chan Choi, Arnaud Michel Gelb, Tao Yang, Gaétan Charles Antoine Giriat, Mithilesh Nayak, Linlin Cao, Jiayun Shen, Donghyun Kim, Lei Li, Yiming Li, Xiao Wang

We measure the branching fraction and time-dependent CP-violating asymmetry for B-0 -> /psi pi(0) decays using a data sample of 711 fb(-1) collected on the Gamma(4S) resonance by the Belle experiment running at the KEKB e(+)e(-) collider. The branching fra ...

American Physical Society2018

Search for the lepton-flavor-violating decay B-0 -> K-*0 mu(+/-)e(-/+)

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Hiroyasu Yamamoto, Taoufiq Harach, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Gaétan Charles Antoine Giriat, Jun Yong Kim, Linlin Cao, Jiayun Shen, Tara Nanut, Donghyun Kim, Martin Lubej, Chang-Hyun Park, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

We have searched for the lepton-flavor-violating decay B-0 -> K-*0 mu(+/-)e(-/+) using a data sample of 711 fb(-1) that contains 772 x 10(6) B (B) over bar pairs. The data were collected near the Upsilon(4S) resonance with the Belle detector at the KEKB as ...

American Physical Society2018

Observation of e(+) e(-) -> pi(+) pi(-) pi(0)chi(b1,2) (1P) and search for e(+) e (-) -> phi chi(b1,2) (1P) at root s=10.96-11.05 GeV

Roberto Gargiani, Olivier Schneider, Sun Hee Kim, Tagir Aushev, Mingkui Wang, Chao Wang, Hiroyasu Yamamoto, Yong Chan Choi, Seyed Sina Mirrazavi Salehian, Arnaud Michel Gelb, Gaétan Charles Antoine Giriat, Jun Yong Kim, Linlin Cao, Jiayun Shen, Tara Nanut, Donghyun Kim, Martin Lubej, Chang-Hyun Park, Lei Li, Ji Hyun Kim, Yiming Li, Xiao Wang

We report searches for the processes e(+) e(-) -> pi(+)pi(-)pi(0)chi(bJ) and e(+) e(-) -> phi chi(bJ) ( J = 1, 2) based on data samples collected by the Belle experiment at the KEKB collider. We report the first observation of the process e(+) e(-) -> (pi( ...

American Physical Society2018

Computational Fluid Dynamics-Based Pump Redesign to Improve Efficiency and Decrease Unsteady Radial Forces

Ning Chu, Linlin Cao, Shuai Yang, Peng Wu

In this study, a double volute centrifugal pump with relative low efficiency and high vibration is redesigned to improve the efficiency and reduce the unsteady radial forces with the aid of unsteady computational fluid dynamics (CFD) analysis. The concept ...

Asme2017