Publications de Pierre-Benoit Bernard Ancey

Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapy

Caroline Anne-Lyse Contat, Etienne Meylan, Gael Luis Boivin, Pierre-Benoit Bernard Ancey

The anti-Ly6G antibody is used to deplete Ly6G(pos) neutrophils and study their role in diverse pathologies. However, depletion is never absolute, as Ly6G(low) neutrophils resistant to depletion rapidly emerge. Studying the functionality of these residual ...

2021

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Nadine Fournier, Caroline Anne-Lyse Contat, Etienne Meylan, Justine Pascual, Gael Luis Boivin, Pierre-Benoit Bernard Ancey, Silvia Sabatino

Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In cancer, pro- or antitumor properties have been attributed to tumor-associated neutrophils (TAN). Here, focusing on TAN accumulation within lung tumors, we id ...

AMER ASSOC CANCER RESEARCH2021

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Bernard Lanz, Graham Knott, Rolf Gruetter, Nadine Fournier, Caroline Anne-Lyse Contat, Mario Gaetano Lepore, Etienne Meylan, Anders Meibom, Stéphane Laurent Escrig, Justine Pascual, Louise Helene Soegaard Jensen, Anouk Rossier, Pierre-Benoit Bernard Ancey, Silvia Sabatino, Inti Zlobec

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

2020

Durable and controlled depletion of neutrophils in mice

Caroline Anne-Lyse Contat, Etienne Meylan, Jessica Christine Vazquez, Justine Pascual, Julien Robert Rémi Faget, Gael Luis Boivin, Pierre-Benoit Bernard Ancey, Aspasia Gkasti

Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective ...

Nature Research2020

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Caroline Anne-Lyse Contat, Etienne Meylan, Pierre-Benoit Bernard Ancey

Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose usage. The upregulation of GLUTs has been reported in numerous cancer types as a result of perturbation of gene expression or protein relocalization or sta ...

WILEY2018

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Paolo Angelino, Olivier Michielin, Mauro Delorenzi, Etienne Meylan, Jessica Christine Vazquez, Stefania Crippa, Pierre-Benoit Bernard Ancey

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017