Andrew Charles Oates

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Publications associées (29)

Delta-Notch signalling in segmentation

Andrew Charles Oates

Modular body organization is found widely across multicellular organisms, and some of them form repetitive modular structures via the process of segmentation. It's vastly interesting to understand how these regularly repeated structures are robustly genera ...

Elsevier Sci Ltd2017

Timing by rhythms: Daily clocks and developmental rulers

Andrew Charles Oates

Biological rhythms are widespread, allowing organisms to temporally organize their behavior and metabolism in advantageous ways. Such proper timing of molecular and cellular events is critical to their development and health. This is best understood in the ...

2016

Object segmentation and ground truth in 3D embryonic imaging

Andrew Charles Oates

Many questions in developmental biology depend on measuring the position and movement of individual cells within developing embryos. Yet, tools that provide this data are often challenged by high cell density and their accuracy is difficult to measure. Her ...

2016

Sequential pattern formation governed by signaling gradients

Andrew Charles Oates

Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of cel ...

2016

Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

Andrew Charles Oates

In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a "segmentation clock". This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression patterns in ...

2016

Correction: Object Segmentation and Ground Truth in 3D Embryonic Imaging

Andrew Charles Oates

2016

Genetic Oscillations and Vertebrate Embryonic Development

Andrew Charles Oates, Daniele Soroldoni

2016

Faster embryonic segmentation through elevated Delta-Notch signalling

Andrew Charles Oates

An important step in understanding biological rhythms is the control of period. A multicellular, rhythmic patterning system termed the segmentation clock is thought to govern the sequential production of the vertebrate embryo's body segments, the somites. ...

Nature Publishing Group2016

Topology and dynamics of the zebrafish segmentation clock core circuit

Bart Deplancke, Sebastian Maerkl, Alina Isakova, Andrew Charles Oates, Daniele Soroldoni

During vertebrate embryogenesis, the rhythmic and sequential segmentation of the body axis is regulated by an oscillating genetic network termed the segmentation clock. We describe a new dynamic model for the core pace-making circuit of the zebrafish segme ...

2012

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