Publications de Takuya Morishita

Impact of spindle-inspired transcranial alternating current stimulation during a nap on sleep-dependent motor memory consolidation in healthy older adults

Manon Chloé Durand-Ruel, Friedhelm Christoph Hummel, Takuya Morishita, Roberto Felipe Salamanca Giron, Maeva Moyne

With the increase in life expectancy and the rapid evolution of daily life technologies, older adults must constantly learn new skills to adapt to society. Sleep reinforces skills acquired during the day and is associated with the occurrence of specific os ...

Oxford University Press (OUP)2025

Robotic-Aided Training and Assessment of Upper Limb Muscle Coordination Following Stroke

Claudia Bigoni, Friedhelm Christoph Hummel, Takuya Morishita

Technology-aided interventions and assessments are at the base of personalized motor rehabilitation after stroke. In the AVANCER trial, the effects of a novel personalized neurotech intervention were assessed by using an instrumented Fugl-Meyer (FM) evalua ...

Springer Nature Switzerland2025

Brain Oscillatory Modes as a Proxy of Stroke Recovery

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Nathalie Heidi Meyer, Elena Beanato, Julia Brügger, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Giorgia Giulia Evangelista, Andéol Geoffroy Cadic-Melchior, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

Background Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery is ...

SAGE Publications2025

Color-induced cognitive conflicts affect muscle activity prior to gait initiation in the Go/No-go task

Takuya Morishita

Introduction: In traffic rule, green/blue means go, and red means stop. It has been shown that this prior knowledge about traffic signal colors can affect reaction times (RTs). For example, RTs are longer when responding to a red “Go” signal and withholdin ...

2024

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Elena Beanato, Esra Neufeld, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Traian Popa, Pierre Theopistos Vassiliadis, Julie Duqué, Fabienne Windel

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Nature Portfolio2024

Stroke Recovery–Related Changes in Cortical Reactivity Based on Modulation of Intracortical Inhibition

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Elena Beanato, Takuya Morishita, Giorgia Giulia Evangelista, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial m ...

Ovid Technologies (Wolters Kluwer Health)2024

Brain connectome correlates of short-term motor learning in healthy older subjects

Manon Chloé Durand-Ruel, Friedhelm Christoph Hummel, Takuya Morishita, Maeva Moyne, Chang-Hyun Park

The motor learning process entails plastic changes in the brain, especially in brain network reconfigurations. In the current study, we sought to characterize motor learning by determining changes in the coupling behaviour between the brain functional and ...

Elsevier Masson, Corp Off2023

Multi-focal Stimulation of the Cortico-cerebellar Loop During the Acquisition of a Novel Hand Motor Skill in Chronic Stroke Survivors

Manon Chloé Durand-Ruel, Pablo Maceira Elvira, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Laurijn Rianne Draaisma, Philipp Johannes Koch

Impairment of hand motor function is a frequent consequence after a stroke and strongly determines the ability to regain a self-determined life. An influential research strategy for improving motor deficits is the combined application of behavioral trainin ...

2023

Novel personalized treatment strategy for patients with chronic stroke with severe upper-extremity impairment: The first patient of the AVANCER trial

Sylvain Jean-François Harquel, Andrea Crema, Elena Beanato, Claudia Bigoni, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Giorgia Giulia Evangelista, Sarah Bernardina Zandvliet

Background: Around 25% of patients who have had a stroke suffer from severe upper-limb impairment and lack effective rehabilitation strategies. The AVANCER proof-of-concept clinical trial (NCT04448483) tackles this issue through an intensive and personaliz ...

CELL PRESS2023

Computer vision-based algorithm to sUppoRt coRrect electrode placemeNT (CURRENT) for home-based electric non-invasive brain stimulation

Jean-Philippe Thiran, Roser Vinals Terres, Friedhelm Christoph Hummel, Takuya Morishita, Rémy Marc M Gardier, Fabienne Windel

Objective: Home-based non-invasive brain stimulation (NIBS) has been suggested as an adjunct treatment strategy for neuro-psychiatric disorders. There are currently no available solutions to direct and monitor correct placement of the stimulation electrode ...

2023

Differential Impact of Brain Network Efficiency on Poststroke Motor and Attentional Deficits

Dimitri Nestor Alice Van De Ville, Philip Egger, Nathalie Heidi Meyer, Elena Beanato, Gabriel Girard, Julia Brügger, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Giorgia Giulia Evangelista, Andéol Geoffroy Cadic-Melchior, Lisa Aïcha Mireille Julie Fleury

Background:Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretic ...

2023

Early motor skill acquisition in healthy older adults: brain correlates of the learning process

Manon Chloé Durand-Ruel, Pablo Maceira Elvira, Friedhelm Christoph Hummel, Takuya Morishita, Maeva Moyne, Chang-Hyun Park

Motor skill learning is a crucial process at all ages. However, healthy aging is often accompanied by a reduction in motor learning capabilities. This study characterized the brain dynamics of healthy older adults during motor skill acquisition and identif ...

OXFORD UNIV PRESS INC2023

Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

Elena Beanato, Pablo Maceira Elvira, Esra Neufeld, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Chang-Hyun Park, Traian Popa, Pierre Theopistos Vassiliadis, Pauline Menoud, Fabienne Windel

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-co ...

Nature Portfolio2023

Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Olaf Blanke, Philip Egger, Sylvain Jean-François Harquel, Silvestro Micera, Nathalie Heidi Meyer, Elena Beanato, Valérie Rita Madeleine Zufferey, Gabriel Girard, Julia Brügger, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Estelle Emeline Raffin, Andéol Geoffroy Cadic-Melchior, Traian Popa, Pauline Menoud, Lisa Aïcha Mireille Julie Fleury

Despite recent improvements, complete motor recovery occurs in < 15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the preci ...

FRONTIERS MEDIA SA2022

Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial protocol

Jean-Philippe Thiran, Roser Vinals Terres, Friedhelm Christoph Hummel, Takuya Morishita, Rémy Marc M Gardier, Fabienne Windel

Enhanced behavioral interventions are gaining increasing interest as innovative treatment strategies for major depressive disorder (MDD). In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompass ...

SPRINGER HEIDELBERG2022

An automatized method to determine latencies of motor-evoked potentials under physiological and pathophysiological conditions

Claudia Bigoni, Friedhelm Christoph Hummel, Takuya Morishita, Andéol Geoffroy Cadic-Melchior, Pierre Theopistos Vassiliadis

Background. Latencies of motor evoked potentials (MEPs) can provide insights into the motor neuronal pathways activated by transcranial magnetic stimulation. Notwithstanding its clinical relevance, accurate, unbiased methods to automatize latency detection ...

IOP Publishing Ltd2022

Evaluating reproducibility and subject-specificity of microstructure-informed connectivity

Jean-Philippe Thiran, Tobias Kober, Elda Fischi Gomez, Tom Hilbert, Elena Beanato, Gabriel Girard, Julia Brügger, Gian Franco Piredda, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Erick Jorge Canales Rodriguez, Marco Pizzolato, Andéol Geoffroy Cadic-Melchior, Chang-Hyun Park

Tractography enables identifying and evaluating the healthy and diseased brain's white matter pathways from diffusion-weighted magnetic resonance imaging data. As previous evaluation studies have reported significant false-positive estimation biases, recen ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

A Novel Patient-Tailored, Cumulative Neurotechnology-Based Therapy for Upper-Limb Rehabilitation in Severely Impaired Chronic Stroke Patients: The AVANCER Study Protocol

Andrea Crema, Elena Beanato, Claudia Bigoni, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Giorgia Giulia Evangelista, Sarah Bernardina Zandvliet

Effective, patient-tailored rehabilitation to restore upper-limb motor function in severely impaired stroke patients is still missing. If suitably combined and administered in a personalized fashion, neurotechnologies offer a large potential to assist reha ...

FRONTIERS MEDIA SA2022

Targeting the frontoparietal network using bifocal transcranial alternating current stimulation during a motor sequence learning task in healthy older adults

Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Laurijn Rianne Draaisma

Background: Healthy older adults show a decrease in motor performance and motor learning capacity as well as in working memory (WM) performance. WM has been suggested to be involved in motor learning processes, such as sequence learning. Correlational evid ...

2022

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Tobias Kober, Elda Fischi Gomez, Alessandro Daducci, Tom Hilbert, Elena Beanato, Gabriel Girard, Julia Brügger, Gian Franco Piredda, Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Philipp Johannes Koch, Erick Jorge Canales Rodriguez, Marco Pizzolato, Andéol Geoffroy Cadic-Melchior, Thomas Yu, Chang-Hyun Park

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022