Publications de Dunja Simicic | EPFL Graph Search

Fast High-Resolution Metabolite Mapping in the rat Brain Using 1H-FID-MRSI at 14.1 T

Bernard Lanz, Cristina Ramona Cudalbu, Thanh Phong Kevin Lê, Dunja Simicic, Jessie Julie Mosso

Magnetic resonance spectroscopic imaging (MRSI) enables the simultaneous noninvasive acquisition of MR spectra from multiple spatial locations inside the brain. Although 1H-MRSI is increasingly used in the human brain, it is not yet widely applied in the p ...

2025

Heterozygous females from a rat model for creatine transporter deficiency reveal altered behavioral response to stressors, normal body weight and slight metabolic changes

Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu, Dunja Simicic

Creatine (Cr) is an organic acid essential for recycling ATP, important in tissues with high energy demand such as muscle or brain. Cr is synthesized in a 2-step pathway by the enzymes AGAT and GAMT, and transported by SLC6A8 (also called CrT). Cerebral Cr ...

2025

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Dunja Simicic, Jessie Julie Mosso

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Frontiers Media Sa2024

Noise-reduction techniques for 1H-FID-MRSI at 14.1 T: Monte Carlo validation and in vivo application

Bernard Lanz, Cristina Ramona Cudalbu, Thanh Phong Kevin Lê, Dunja Simicic, Jessie Julie Mosso

Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a powerful tool that enables the multidimensional non-invasive mapping of the neurochemical profile at high resolution over the entire brain. The constant demand for higher spatial resolution in ...

Wiley2024

Inhibition of urease-mediated ammonia production by 2-octynohydroxamic acid in hepatic encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in t ...

Nature Portfolio2024

Brain Regional Differences in the Developing Brain Using an Animal Model of Type C Hepatic Encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

The Beneficial Effect of Oral Cr Supplementation in an Early Childhood Rat Model of Chronic Hepatic Encephalopathy: In Vivo Longitudinal 1H and 31P Magnetic Resonance Spectroscopy Study

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

Central Nervous System Oxidative Stress interplay with inflammation in a rat model of Type C Hepatic Encephalopathy - brothers in arms?

Andrzej Sienkiewicz, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2023

Evaluation of a Hydroxamate-Based Urease Inhibitor in a Rodent Model of Hepatic Encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

Lippincott Williams & Wilkins2023

Neurometabolic profiles of bile duct ligated rats after the treatment with an urease inhibitor – 1H MRS dataset

Cristina Ramona Cudalbu, Dunja Simicic

1H MRS in the cerebellum was used to study the effect of 2-octynohydroxamic acid (2-octynoHA) treatment on the brain of bile duct ligated (BDL) rats (type C hepatic encephalopathy). The study included four groups of rats: negative control group (rats recei ...

Zenodo2023

Age Dependence of Neurometabolic Changes in a Rat Pup Model of Type C Hepatic Encephalopathy

Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Lippincott Williams & Wilkins2023

Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu, Dunja Simicic, Jessie Julie Mosso

PurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites in diffusion-weighted MRS (DWS).MethodsA new sequence for single-voxel diffusion-weighted 1H MR spectroscopy, named DW-SPECIAL, is propo ...

WILEY2023

New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

Bernard Lanz, Carole Poitry-Yamate, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Dunja Simicic, Ting Yin, Jessie Julie Mosso

Lippincott Williams & Wilkins2023

Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset

Cristina Ramona Cudalbu, Veronika Rackayová, Dunja Simicic

Chronic liver disease (CLD) is a serious condition where various toxins present in the blood affect the brain leading to type C hepatic encephalopathy (HE). Both adults and children are impacted, while children may display unique vulnerabilities depending ...

SPRINGER/PLENUM PUBLISHERS2023

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

Cristina Ramona Cudalbu, Dunja Simicic

Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Abnormal brain oxygen homeostasis in an animal model of liver disease

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Dunja Simicic

Background & Aims: Increased plasma ammonia concentration and consequent disruption of brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE). Brain energy homeostasis relies on effective maintenance of brain oxygenation, an ...

ELSEVIER2022

Central Nervous System Oxidative Stress Interplay With Inflammation In A Rat Model Of Type C Hepatic Encephalopathy - Brothers In Arms?

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2022

Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

Andrzej Sienkiewicz, Rolf Gruetter, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

The role and coexistence of oxidative stress (OS) and inflammation in type C hepatic encephalopathy (C HE) is a subject of intense debate. Under normal conditions the physiological levels of intracellular reactive oxygen species are controlled by the count ...

2022

Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy (vol 178, pg 295, 2022)

Andrzej Sienkiewicz, Rolf Gruetter, Katarzyna Pierzchala, Cristina Ramona Cudalbu, Stefanita-Octavian Mitrea, Dunja Simicic

ELSEVIER SCIENCE INC2022

MP-PCA denoising for diffusion MRS data: promises and pitfalls

Cristina Ramona Cudalbu, Dunja Simicic, Jessie Julie Mosso

Diffusion-weighted (DW) magnetic resonance spectroscopy (MRS) suffers from a lower signal to noise ratio (SNR) compared to conventional MRS owing to the addition of diffusion attenuation. This technique can therefore strongly benefit from noise reduction s ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022