Publications de Giovanni Sorrentino

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Kristina Schoonjans, Johan Auwerx, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam, Antoine Jalil

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Kristina Schoonjans, Giovanni Sorrentino

Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2 diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 secretion and L-cell abundance. Here we identify G-protein-coupled bile acid receptor ...

AMER DIABETES ASSOC2020

Mechano-modulatory synthetic niches for liver organoid derivation

Matthias Lütolf, Kristina Schoonjans, Saba Rezakhani, Ece Yildiz, Giovanni Sorrentino

The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling. The use of three-dimensional (3D) cultures based on ill-defined and potentially immunog ...

Nature Publishing Group2020

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Maroun Bou Sleiman, Alessia Perino, Ece Yildiz, Giovanni Sorrentino, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020

Three dimensional models of tissue fibrosis

Matthias Lütolf, Kristina Schoonjans, Saba Rezakhani, Ece Yildiz, Giovanni Sorrentino

The invention provides a method for obtaining a three-dimensional (3D) cellular model of tissue fibrosis, such as liver fibrosis, comprising culturing epithelial cells in a 3D hydrogel in conditions suitable for a three-dimensional cellular cluster formati ...

2020

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Giovanni Sorrentino

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholi ...

Springer2019

Giovanni Sorrentino

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Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Mechano-modulatory synthetic niches for liver organoid derivation

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Three dimensional models of tissue fibrosis

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

GDA, a web-based tool for Genomics and Drugs integrated analysis

Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis

The stiff RhoAd from mevalonate to mutant p53