Publications de Stefano Lai | EPFL Graph Search

Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery

Marco Mainardi, Silvestro Micera, Sara Conti, Maria Pasquini, Stefano Lai

Despite recent progresses in robotic rehabilitation technologies, their efficacy for post-stroke motor recovery is still limited. Such limitations might stem from the insufficient enhancement of plasticity mechanisms, crucial for functional recovery. Here, ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Silvestro Micera, Francesco Saverio Pavone, Stefano Lai

Rehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by rehabilitative ther ...

2019

A Robotic System for Adaptive Training and Function Assessment of Forelimb Retraction in Mice

Silvestro Micera, Sara Conti, Maria Pasquini, Stefano Lai

Rodent models are decisive for translational research in healthy and pathological conditions of motor function thanks to specific similarities with humans. Here, we present an upgraded version of the M-Platform, a robotic device previously designed to trai ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2018

A Murine Model of Robotic Training to Evaluate Skeletal Muscle Recovery after Injury

Silvestro Micera, Stefano Lai

LAI, S., A. PANARESE, R. LAWRENCE, M. L. BONINGER, S. MICERA, and F. AMBROSIO. A Murine Model of Robotic Training to Evaluate Skeletal Muscle Recovery after Injury. Med. Sci. Sports Exerc., Vol. 49, No. 4, pp. 840-847, 2017. Purpose: In vivo studies have s ...

American College of Sports Medicine2017

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

Silvestro Micera, Stefano Lai

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective str ...

Frontiers Media Sa2017

Reducing GABA(A)-mediated inhibition improves forelimb motor function after focal cortical stroke in mice

Silvestro Micera, Stefano Lai

A deeper understanding of post-stroke plasticity is critical to devise more effective pharmacological and rehabilitative treatments. The GABAergic system is one of the key modulators of neuronal plasticity, and plays an important role in the control of "cr ...

Nature Research2016

Robotic rehabilitation- and plasticizing treatments-mediated motor recovery in a mouse model of ischemic injury

Silvestro Micera, Stefano Lai

Karger2016

Quantitative Kinematic Characterization of Reaching Impairments in Mice After a Stroke

Silvestro Micera, Stefano Lai

Background and Objective. Kinematic analysis of reaching movements is increasingly used to evaluate upper extremity function after cerebrovascular insults in humans and has also been applied to rodent models. Such analyses can require time-consuming frame- ...

Sage Publications Inc2015

A Robotic System for Quantitative Assessment and Poststroke Training of Forelimb Retraction in Mice

Marco Mainardi, Silvestro Micera, Stefano Lai

Background. Neurorehabilitation protocols based on the use of robotic devices have recently shown to provide promising clinical results. However, their efficacy is still limited because of the poor comprehension of the mechanisms at the basis of functional ...

Sage Publications Inc2014