Publications de Alexiane Clara Decout

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

The cGAS-STING pathway drives innate immune activation in response to cytosolic DNA. This is important for immunity to bacteria and viruses, but aberrant cGAS-STING activity is also linked to inflammatory disease. Here, Ablasser and colleagues discuss how ...

NATURE RESEARCH2021

Structural mechanism of cGAS inhibition by the nucleosome

Rudolf Hovius, Simone Cavadini, Beat Fierz, Andrea Ablasser, Sélène-Véronique Glück, Baptiste Claude André Guey, Alexiane Clara Decout, Kristina Makasheva, Pauline Ambre Melenec

The DNA sensor cGAS initiates innate immune responses following microbial infection, cellular stress, and cancer1. Upon activation by double-stranded DNA, cytosolic cGAS produces 2’3’ cyclic GMP-AMP and triggers inflammatory cytokine and type I interferon ...

2020

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

Beat Fierz, Andrea Ablasser, Mahmut Selman Sakar, Murat Kaynak, Baptiste Claude André Guey, Alexiane Clara Decout, Marilena Wischnewski, Kristina Makasheva

The appearance of DNA in the cytosol is perceived as a danger signal that stimulates potent immune responses through cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS). How cells regulate the activity of cGAS toward self-DNA and guard a ...

American Association for the Advancement of Science2020

Virology: Poxins Soothe the STING

Andrea Ablasser, Alexiane Clara Decout

The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham ...

CELL PRESS2019

Human cGAS Has a Slightly Different Taste for dsDNA

Andrea Ablasser, Alexiane Clara Decout

2018

Targeting STING with covalent small-molecule inhibitors

Gerardo Turcatti, Luc Reymond, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Andrea Ablasser, Muhammet Fatih Gülen, Simone Margret Haag, Michael Christian Heymann, Alexiane Clara Decout

2018

Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Alexiane Clara Decout

Dectin-2 is a C-type lectin involved in the recognition of several pathogens such as Aspergillus fumigatus, Candida albicans, Schistosoma mansonii, and Mycobacterium tuberculosis that triggers Th17 immune responses. Identifying pathogen ligands and underst ...

Nature Research2018