Publications de Francesco La Rosa

Streamline RimNet: Tools for Automatic Classification of Paramagnetic Rim Lesions in MRI of Multiple Sclerosis

Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

This site provides two software tools related to "RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis" by Barquero et al. NeuroImage: Clinical (2020). People using in part or f ...

Zenodo2023

Toward a joint automated assessment of cortical and paramagnetic rim lesions with 7T MRI

Meritxell Bach Cuadra, Francesco La Rosa

SAGE PUBLICATIONS LTD2022

BMAT: An open-source BIDS managing and analysis tool

Meritxell Bach Cuadra, Benoît Macq, Francesco La Rosa, Maxence Charles F Wynen

Magnetic Resonance Imaging (MRI) is an established technique to study in vivo neurological disorders such as Multiple Sclerosis (MS). To avoid errors on MRI data organization and automated processing, a standard called Brain Imaging Data Structure (BIDS) h ...

ELSEVIER SCI LTD2022

Fluid and White Matter Suppression New Sensitive 3 T Magnetic Resonance Imaging Contrasts for Cortical Lesion Detection in Multiple Sclerosis

Meritxell Bach Cuadra, Francesco La Rosa

Objective Cortical lesions are common in multiple sclerosis (MS), but their visualization is challenging on conventional magnetic resonance imaging. The uniform image derived from magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE(uni)) de ...

LIPPINCOTT WILLIAMS & WILKINS2022

Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

The current diagnostic criteria for multiple sclerosis (MS) lack specificity, and this may lead to misdiagnosis, which remains an issue in present-day clinical practice. In addition, conventional biomarkers only moderately correlate with MS disease progres ...

ELSEVIER SCI LTD2022

Multiple sclerosis cortical lesion detection with deep learning at ultra-high-field MRI

Jean-Philippe Thiran, Francesco La Rosa

Manually segmenting multiple sclerosis (MS) cortical lesions (CLs) is extremely time consuming, and past studies have shown only moderate inter-rater reliability. To accelerate this task, we developed a deep-learning-based framework (CLAIMS: Cortical Lesio ...

WILEY2022

Deep learning-based analysis of multiple sclerosis lesions with high and ultra-high field MRI

Francesco La Rosa

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and affects almost 3 million people worldwide. There is currently no cure for MS, and its symptoms, starting with fatigue and weakness, often progress over time ...

EPFL2022

GAMER-MRI in Multiple Sclerosis Identifies the Diffusion-Based Microstructural Measures That Are Most Sensitive to Focal Damage: A Deep-Learning-Based Analysis and Clinico-Biological Validation

Meritxell Bach Cuadra, Francesco La Rosa

Conventional magnetic resonance imaging (cMRI) in multiple sclerosis (MS) patients provides measures of focal brain damage and activity, which are fundamental for disease diagnosis, prognosis, and the evaluation of response to therapy. However, cMRI is ins ...

FRONTIERS MEDIA SA2021

CLaiMS-Net: cortical lesions assessment in multiple sclerosis patients via a convolutional neural network and a single 3T MRI acquisition

Jean-Philippe Thiran, Meritxell Bach Cuadra, Cristina Granziera, Po-Jui Lu, Muhamed Barakovic, Francesco La Rosa

SAGE PUBLICATIONS LTD2021

An assessment of intra-scanner reproducibility of myelin-sensitive MRI measures

Meritxell Bach Cuadra, Cristina Granziera, Po-Jui Lu, Muhamed Barakovic, Lester Melie Garcia, Francesco La Rosa, Yi Wang

SAGE PUBLICATIONS LTD2021

Automated detection of cortical lesions with single and multi-contrast 7T MRI

Jean-Philippe Thiran, Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa

SAGE PUBLICATIONS LTD2021

MPRAGE to MP2RAGE UNI translation via generative adversarial network improves the automatic tissue and lesion segmentation in multiple sclerosis patients

Jean-Philippe Thiran, Meritxell Bach Cuadra, Cristina Granziera, Thomas Yu, Francesco La Rosa

Background and objective: Compared to the conventional magnetization-prepared rapid gradient-echo imaging (MPRAGE) MRI sequence, the specialized magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) shows a higher brain tissue and lesion con ...

2021

Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging

Meritxell Bach Cuadra, Francesco La Rosa

Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple sclerosis; however, a detailed characterization of the interaction between myelin and axon damage in vivo remains challenging. ...

OXFORD UNIV PRESS2021

Chronic White Matter Inflammation and Serum Neurofilament Levels in Multiple Sclerosis

Meritxell Bach Cuadra, Francesco La Rosa

Objective To assess whether chronic white matter inflammation in patients with multiple sclerosis (MS) as detected in vivo by paramagnetic rim MRI lesions (PRLs) is associated with higher serum neurofilament light chain (sNfL) levels, a marker of neuroaxon ...

LIPPINCOTT WILLIAMS & WILKINS2021

Cortical lesion detection using FLAWS in multiple sclerosis

Meritxell Bach Cuadra, Francesco La Rosa

SAGE PUBLICATIONS LTD2021

GAMER MRI: Gated-attention mechanism ranking of multi-contrast MRI in brain pathology

Meritxell Bach Cuadra, Francesco La Rosa

Introduction: During the last decade, a multitude of novel quantitative and semiquantitative MRI techniques have provided new information about the pathophysiology of neurological diseases. Yet, selection of the most relevant contrasts for a given patholog ...

2021

Automated assessment of paramagnetic rim lesions in multiple sclerosis patients with 3T and 7T MP2RAGE

Jean-Philippe Thiran, Meritxell Bach Cuadra, Bénédicte Marie Maréchal, Tobias Kober, Cristina Granziera, Francesco La Rosa

Paramagnetic rim lesions (PRL) in multiple sclerosis are chronic inflammatory lesions depicted in susceptibility-based MRI where high PRL lesion burden has been associated with a more aggressive disease course. As their visual detection is subjective and t ...

ISMRM2021

Studying intralesional axonal damage in ms white matter lesions with diffusion mri biophysical models

Francesco La Rosa

SAGE PUBLICATIONS LTD2020

Multiple sclerosis cortical and WM lesion segmentation at 3T MRI: a deep learning method based on FLAIR and MP2RAGE

Jean-Philippe Thiran, Meritxell Bach Cuadra, Ahmed Abdulkadir, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu, Muhamed Barakovic, Francesco La Rosa

The presence of cortical lesions in multiple sclerosis patients has emerged as an important biomarker of the disease. They appear in the earliest stages of the illness and have been shown to correlate with the severity of clinical symptoms. However, cortic ...

2020

Translating mprage to mp2rage improves the automatic tissue and lesion segmentation in multiple sclerosis patients

Jean-Philippe Thiran, Thomas Yu, Francesco La Rosa

SAGE PUBLICATIONS LTD2020