Publications de Alessandro Enrico Foni

Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling

Georges Khazen, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Adrien Christian Fleury, Jay Coggan, Judit Planas Carbonell, Juan José García Cantero, Alessandro Enrico Foni, Nadir Roman Guerrero, Elvis Boci

Understanding the intracellular dynamics of brain cells entails performing three-dimensional molecular simulations incorporating ultrastructural models that can capture cellular membrane geometries at nanometer scales. While there is an abundance of neuron ...

Oxford University Press (OUP)2024

Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience

Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Eleftherios Zisis, Jay Coggan, Juan José García Cantero, Alessandro Enrico Foni, Nadir Roman Guerrero

Ultraliser is a neuroscience-specific software framework capable of creating accurate and biologically realistic 3D models of complex neuroscientific structures at intracellular (e.g. mitochondria and endoplasmic reticula), cellular (e.g. neurons and glia) ...

2023

Meshing of Spiny Neuronal Morphologies using Union Operators

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Juan José García Cantero, Alessandro Enrico Foni, Nadir Roman Guerrero, Elvis Boci

Neurons are characterized by thin and long interleaving arborizations in which creating accurate mesh models of their cellular membranes is challenging. While union operators are central for CAD/CAM modeling and computer graphics applications, their applic ...

2022

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Eleftherios Zisis, Jay Coggan, Samuel Lieven D. Lapere, Alessandro Enrico Foni, Nadir Roman Guerrero

Motivation: Astrocytes, the most abundant glial cells in the mammalian brain, have an instrumental role in developing neuronal circuits. They contribute to the physical structuring of the brain, modulating synaptic activity and maintaining the blood-brain ...

OXFORD UNIV PRESS2021

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Kathryn Hess Bellwald, Henry Markram, Felix Schürmann, Corrado Cali, Alexis Arnaudon, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Lida Kanari, Eleftherios Zisis, Michael Emiel Gevaert, Benoît Jean-Albert Coste, Thomas Brice Delemontex, Alessandro Enrico Foni

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

High Fidelity Visualization of Large Scale Digitally Reconstructed Brain Circuitry with Signed Distance Functions

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Sébastien Nicolas Speierer, Samuel Lieven D. Lapere, Jonas Kristofer Karlsson, Alessandro Enrico Foni

We explore a first proof-of-concept application for visualizing large scale digitally reconstructed brain circuitry using signed distance functions. The significance of our method is demonstrated in comparison with using implicit geometry that is limited t ...

IEEE2019