Publications de Adrien Jules Louis Madron Du Vigné

Chiral Cyclic Alkyl Amino Carbenes as Ancillary Ligands for Asymmetric Catalysis

N-Heterocyclic carbenes (NHCs) are privileged ligands in catalysis and especially for asymmetric transformations. Cyclic Alkyl Amino Carbenes (CAACs) are NHCs analogs displaying unique steric and electronic features. While CAAC organometallic complexes wer ...

EPFL2025

Systematic Synthesis of Chiral CAACs with Three Independent Stereogenic Centers for Enantioselective Copper-Catalyzed Conjugate Borylation of Michael Acceptors

Nicolai Cramer, Adrien Jules Louis Madron Du Vigné

Chiral cyclic alkyl amino carbenes (CAACs), an intriguing subclass of N-heterocyclic carbenes, hold promising potential in asymmetric catalysis. Yet, synthetic hurdles and a lack of understanding of dominant selectivity-inducing design elements prevent the ...

American Chemical Society (ACS)2025

Streamlined synthetic assembly of α-chiral CAAC ligands and catalytic performance of their copper and ruthenium complexes

Nicolai Cramer, Adrien Jules Louis Madron Du Vigné

The unique electronic and steric parameters of chiral cyclic alkyl amino carbene (CAAC) ligands render them appealing steering ligands for enantioselective transition-metal catalyzed transformations. Due to the lack of efficient synthetic strategies to acc ...

2024

Chiral Cyclic Alkyl Amino Carbene (CAAC) Transition-Metal Complexes: Synthesis, Structural Analysis, and Evaluation in Asymmetric Catalysis

Adrien Jules Louis Madron Du Vigné

Despite recent advances in the field of cyclic alkyl amino carbenes (CAACs) including a few complementary synthetic strategies affording CAACs with various substitution patterns, the application potential of chiral CAACs to efficiently catalyze asymmetric ...

2022

Catalytic Enantioselective Functionalizations of C-H Bonds by Chiral Iridium Complexes

Nicolai Cramer, Qui-Hien Nguyen, Jin Fay Tan, Adrien Jules Louis Madron Du Vigné

The development of catalytic enantioselective transformations, enabling the construction of complex molecular scaffolds from simple precursors, has been a long-standing challenge in organic synthesis. Recent achievements in transition-metal catalyzed enant ...

2020