Publications de Michael Alan Wayne

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Michael Alan Wayne

Significance: Diffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective cerebra ...

SPIE-Intl Soc Optical Eng2025

Massively multiplexed wide-field photon correlation sensing

Claudio Bruschini, Edoardo Charbon, Michael Alan Wayne

Temporal photon correlations have been a crucial resource for quantum and quantum-enabled optical science for over half a century. However, attaining non-classical information through these correlations has typically been limited to a single point (or, at ...

2025

Deep blood flow extraction for diffuse correlation spectroscopy at photon-starved regimes using SPAD arrays

Claudio Bruschini, Edoardo Charbon, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is an optical technique that allows for non-invasive measurements of tissue perfusion, and is often used for neuromonitoring applications. However, a major challenge of DCS is low SNR for deep tissue measurements. Rec ...

2024

Piccolo gated: a CMOS 32×32 SPAD camera with all-solid-state nanosecond time gating and PCIe readout for single-photon time-domain DCS and near-infrared optical tomography

Claudio Bruschini, Edoardo Charbon, Scott Anthony Lindner, Tommaso Milanese, Paul Mos, Michael Alan Wayne

The Piccolo gated sensor features a 32x32 SPAD array of single-photon avalanche diodes (SPADs) operating in time-correlated single-photon counting (TCSPC). The chip enables event-driven readout and a maximum count rate of 220 Mcps. The sensor is based on t ...

SPIE2024

Demonstration of particle tracking with scintillating fibres read out by a SPAD array sensor and application as a neutrino active target

Claudio Bruschini, Edoardo Charbon, Paul Mos, Michael Alan Wayne, Kodai Kaneyasu

Scintillating fibre detectors combine sub-mm resolution particle tracking, precise measurements of the particle stopping power and sub-ns time resolution. Typically, fibres are read out with silicon photomultipliers (SiPM). Hence, if fibres with a few hund ...

Springer2024

GPU-based data processing for speeding-up correlation plenoptic imaging

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

Correlation plenoptic imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of CPI is related to ...

2024

Towards Surface-Correction of Deep-Tissue Blood Flow Dynamics with Massively Parallelized Diffuse Correlation Spectroscopy

Claudio Bruschini, Edoardo Charbon, Michael Alan Wayne

Diffuse Correlation Spectroscopy (DCS) allows the optical and label-free investigation of microvascular dynamics. Commonly, DCS is implemented with highly sensitive and ultra fast single-photon avalanche diodes (SPAD) for blood flow measurements from aroun ...

SPIE2024

Efficient signal extraction for diffuse correlation spectroscopy with SPAD arrays at low photon regimes

Claudio Bruschini, Edoardo Charbon, Michael Alan Wayne

SPAD arrays have shown potential for improving SNR for diffuse correlation spectroscopy in low photon regimes. Here, we will explore different methods of integrating parallelized DCS signals in such regimes for deep blood flow extraction. ...

Optical Society of America2024

Quantum ghost imaging microscopy depth-of-field study

Claudio Bruschini, Edoardo Charbon, Paul Mos, Yang Lin, Michael Alan Wayne

Quantum ghost imaging approaches have been proposed to enhance biological microscopy, for example, using 2D visible detectors to provide IR images or providing additional dimensions of spatial or spectral information. Toward the goal of making such imaging ...

2024

Towards precise optical measurements of steady state of and small changes in resting membrane potentials

Claudio Bruschini, Edoardo Charbon, Michael Alan Wayne

CELL PRESS2023

Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera

Claudio Bruschini, Edoardo Charbon, Francesco Marsili, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily ...

2023

A 500 x 500 Dual-Gate SPAD Imager With 100% Temporal Aperture and 1 ns Minimum Gate Length for FLIM and Phasor Imaging Applications

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

In this article, we report on SwissSPAD3 (SS3), a 500 x 500 pixel single-photon avalanche diode (SPAD) array, fabricated in 0.18-mu m CMOS technology. In this sensor, we introduce a novel dual-gate architecture with two contiguous temporal windows, or gate ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Towards quantum 3D imaging devices

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

We introduce a new generation of 3D imaging devices based on quantum plenoptic imaging. Position-momentum entanglement and photon number correlations are exploited to provide a scan-free 3D image after post-processing of the collected light intensity signa ...

2021

Towards Quantum 3D Imaging Devices

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

We review the advancement of the research toward the design and implementation of quantum plenoptic cameras, radically novel 3D imaging devices that exploit both momentum–position entanglement and photon–number correlations to provide the typical refocusin ...

2021