Publications de Qian Zhang | EPFL Graph Search

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (vol 15, 22, 2023)

Jacques Fellay, Qian Zhang, Peng Zhang, Yu Zhang

BMC2024

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi, Qian Zhang, Peng Zhang, Yu Zhang

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia 3 . ...

Nature Portfolio2023

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Jacques Fellay, Qian Zhang, Peng Zhang, Yu Zhang

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvac ...

BMC2023

Adapting the dynamic LakeMab model to simulate seasonal variations of phosphorus concentration in reservoirs: a case study of Lake Bultiere (France)

Camille Roland Marie Minaudo, Qian Zhang

Controlling phosphorus is fundamental to limit the risk of eutrophication of continental aquatic ecosystems. Integrated modelling of its concentration in the aquatic continuum requires specific tools for water bodies. However, although simple static empiri ...

2020

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Jacques Fellay, Zhiyong Liu, Xavier Duval, Rui Yang, Qian Zhang, Juan Li, Jie Chen, Peng Zhang, Yu Zhang

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...

American Association for the Advancement of Science2020

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Friedrich Beermann, Rong Wu, Li Li, Yi Zhang, Jie Zhang, Qian Zhang, Ang Li, Ping Chen, Bo Zhou, Yuan Liu

Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear ...

Nature Publishing Group2014

Guest Editorial: Special issue on wireless multimedia sensor networks

Pascal Frossard, Qian Zhang

2008

Guest Editorial Cross-layer Optimized Wireless Multimedia Communications

Pascal Frossard, Qian Zhang

2007