Publications de Jia Liu | EPFL Graph Search

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Tanes Imamura de Lima, Qi Wang, Jia Liu

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

Mitochondrial genetics, signalling and stress responses

Johan Auwerx, Jia Liu

Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome, which is matrilineally inherited and not sub ...

NATURE PORTFOLIO2025

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Johan Auwerx, Xiaoxu Li, Sandra Rodriguez Lopez, Qi Wang, Jia Liu, Keno Strotjohann

Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD+) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carb ...

2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Alessia De Masi, Amélia Lalou, Jia Liu

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

Search for high-mass exclusive diphoton production with tagged protons in proton-proton collisions at √s=13 TeV

Patrick Berger, Rakesh Chawla, Ian Smith, Jung Eung Park, Thomas Mountford, Matthias Finger, Matteo Galli, Maria Isabel Cordero Campana, Xiaoqiang Wang, Jian Zhao, James Gonzalo King, Mirko Kovac, Hua Zhang, Joo Yeon Kim, Jae-Woo Choi, Pedro Camilo de Oliveira e Silva, Young Min Kim, Myun Sik Kim, Gabriele Grosso, Qian Wang, Varun Sharma, Michele De Palma, Hyungjun Lee, Chia-Chun Chen, Siyuan Wang, Özdemir Can Kara, Shivom Sharma, Jian Wang, Yi Zhang, Bokyoung Kim, Rahul Kumar Gupta, Ling Zhou, Mithlesh Kumar, Chenyang Wang, Matthias Wolf, Chang-Hyun Park, Anna Mascellani, Yikai Yang, Zhenyu Wang, Seonwoo Lee, Wei-Hsiang Lin, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

The second data release from the European Pulsar Timing Array IV. Implications for massive black holes, dark matter, and the early Universe

Andrii Neronov, Ke Liu, Jun Wang, Jongmoon Jang, Jia Liu

The European Pulsar Timing Array (EPTA) and Indian Pulsar Timing Array (InPTA) collaborations have measured a low-frequency common signal in the combination of their second and first data releases, respectively, with the correlation properties of a gravita ...

EDP SCIENCES S A2024

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

Johan Auwerx, Richardus Houtkooper, Krisztian Homicsko, Maroun Bou Sleiman, Xiaoxu Li, Sandra Rodriguez Lopez, Jia Liu, Keno Strotjohann

Lippincott Williams & Wilkins2023

Mitochondria: A "pacemaker"for species-specific development

Johan Auwerx, Jia Liu

We highlight papers by Diaz-Cuadros et al.(1) and Iwata et al.(2) that demonstrate the role of mitochondrial metabolism in setting developmental pace through their control over cellular bioenergetics and redox homeostasis in mice and humans. ...

CELL PRESS2023

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Johan Auwerx, Richardus Houtkooper, Krisztian Homicsko, Maroun Bou Sleiman, Xiaoxu Li, Sandra Rodriguez Lopez, Jia Liu, Keno Strotjohann

Lippincott Williams & Wilkins2023

ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID MODELS OF STEATOHEPATITIS

Johan Auwerx, Jia Liu

WILEY2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Felix Naef, Kristina Schoonjans, Johan Auwerx, Hao Li, Yang Li, Wen Gao, Xiaoxu Li, Amélia Lalou, Nagammal Neelagandan, Jia Liu, Yuan Liu

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Jean-David Horacio Morel, Sandra Rodriguez Lopez, Jia Liu

WILEY2022

Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider

Marco Drewes, Jessica Prisciandaro, Matthieu Philippe Luther Marinangeli, Ennio Salvioni, Victor Coco, Manfredi Ronzani, Patrick Foldenauer, Yi Zhang, Federico Leo Redi, Marco Trovato, Ahmed Hammad, Jia Liu, Giorgia Rauco, Xiao Wang

Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far ...

IOP PUBLISHING LTD2020

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Phuong Nguyen, Han Liang, Jian Wang, Wei Zhang, Li Ding, Jun Li, Min Wang, Luca Mattei, Yi Han, Jia Liu, Wei Li, Hui Shen

Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one ...

2018

Phonon dynamics in CuxBi2Se3 (x=0, 0.1, 0.125) and Bi2Se2 crystals studied using femtosecond spectroscopy

Helmuth Berger, Jia Liu

Phonon dynamics in Bi, Bi2Se2, and CuxBi2Se3 (x=0, 0.1, 0.125) single crystals was investigated using femtosecond pump-probe spectroscopy. Two damped oscillations in measured transient reflectivity changes were observed, respectively, attributed to coheren ...

Amer Inst Physics2012

Crystal Structure and Magnetic Properties of Two New Antiferromagnetic Spin Dimer Compounds; FeTe3O7X (X = Cl, Br)

Helmuth Berger, Dong Zhang, Jia Liu

Two new isostructural layered oxohalides FeTe3O7X (X = Cl, Br) were synthesized by chemical vapor transport reactions, and their crystal structures and magnetic properties were characterized by single-crystal X-ray diffraction, Raman spectroscopy, magnetic ...

2011