Publications de Babatunde Edukpe Ekundayo

Structural basis of SIRT7 nucleosome engagement and substrate specificity

Henning Paul-Julius Stahlberg, Beat Fierz, Dongchun Ni, Babatunde Edukpe Ekundayo, Carlos Moreno Yruela

Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity withi ...

NATURE PORTFOLIO2025

Identification of a binding site for small molecule inhibitors targeting human TRPM4

Henning Paul-Julius Stahlberg, Dongchun Ni, Babatunde Edukpe Ekundayo

Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. The anthranilic acid derivative NBA is a potent and specific TRPM4 inhibitor, but ...

Nature Portfolio2025

Computational drug development for membrane protein targets

Henning Paul-Julius Stahlberg, Pierre Vogel, Shuguang Yuan, Dongchun Ni, Babatunde Edukpe Ekundayo

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

2024

Activation mechanism of a short argonaute-TIR prokaryotic immune system

Henning Paul-Julius Stahlberg, Dongchun Ni, Babatunde Edukpe Ekundayo

Short prokaryotic argonaute (pAgo) and toll/interleukin-1 receptor/resistance protein (TIR)-analog of PAZ (APAZ) form a heterodimeric SPARTA complex that provides immunity to its prokaryotic host through an abortive infection mechanism. Monomeric SPARTA se ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

Henning Paul-Julius Stahlberg, Christof Holliger, Julien Maillard, Lorenzo Cimmino, Dongchun Ni, Babatunde Edukpe Ekundayo

Organohalide-respiring bacteria are key organisms for the bioremediation of soils and aquifers contaminated with halogenated organic compounds. The major players in this process are respiratory reductive dehalogenases, corrinoid enzymes that use organohali ...

Nature Research2023

Structural insights into the regulation of Cas7-11 by TPR-CHAT

Henning Paul-Julius Stahlberg, Sergey Nazarov, Dongchun Ni, Alexander Myasnikov, Babatunde Edukpe Ekundayo

The CRISPR-guided caspase (Craspase) complex is an assembly of the target-specific RNA nuclease known as Cas7-11 bound to CRISPR RNA (crRNA) and an ancillary protein known as TPR-CHAT (tetratricopeptide repeats (TPR) fused with a CHAT domain). The Craspase ...

2023

It takes two times two to tango - cryoEM structure resolution of the membrane-bound tetrachloroethene reductive dehalogenase complex

Christof Holliger, Julien Maillard, Lorenzo Cimmino, Dongchun Ni, Babatunde Edukpe Ekundayo

ELSEVIER2022