Yujia Wang

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Publications associées (4)

Programmable DARPin-based receptors for the detection of thrombotic markers

Haifeng Ye, Leo Scheller, Yujia Wang

Cellular therapies remain constrained by the limited availability of sensors for disease markers. Here we present an integrated target-to-receptor pipeline for constructing a customizable advanced modular bispecific extracellular receptor (AMBER) that comb ...

NATURE PORTFOLIO2022

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Patricia Corthésy Henrioud, Sandrine Madeleine Suzanne Georgeon, Luciano Andres Abriata, Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Jaume Bonet Martinez, Fabian Sesterhenn, Che Yang, Sabrina Susan Vollers, Mélanie Evelyne Villard, Elie Charles Eugène Dheilly, Stéphane Rosset, Yujia Wang

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remain ...

American Association for the Advancement of Science2020

Computational design of anti-CRISPR proteins with improved inhibition potency

Wei Sun, Sandrine Madeleine Suzanne Georgeon, Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld, Andreas Scheck, Stéphane Rosset, Julius Valten Upmeier Zu Belzen, Yujia Wang

Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhibitor, ...

NATURE PUBLISHING GROUP2020

Expanding the druggable proteome: Ligand and target discovery by fragment-based screening in cells

Christopher Parker, Bruno Emanuel Ferreira De Sousa Correia, Yujia Wang

AMER CHEMICAL SOC2018

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