Publications de Alexandre Lemopoulos

West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems

Melanie Blokesch, Sandrine Stutzmann, David William Adams, Milena Jadwiga Jaskolska, Laurie Righi, Loriane Bader, Alexandre Lemopoulos

Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. The West African–South American (WASA) lineage of V. cholerae, responsible for the 1991–2001 Latin American cholera e ...

Springer Science and Business Media LLC2025

Exploring Mobile Genetic Elements in Vibrio cholerae

Melanie Blokesch, Natalia Carolina Drebes Dorr, Alexandre Lemopoulos

Members of the bacterial species Vibrio cholerae are known both as prominent constituents of marine environments and as the causative agents of cholera, a severe diarrheal disease. While strains responsible for cholera have been extensively studied over th ...

Oxford University Press (OUP)2025

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Melanie Blokesch, Sandrine Stutzmann, Natalia Carolina Drebes Dorr, Alexandre Lemopoulos

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

2024

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems

Melanie Blokesch, David William Adams, Grazia Vizzarro, Alexandre Lemopoulos

In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialized defense systems that are often clustered together on genomic islands. The O1 El Tor strains of Vibrio cholerae resp ...

American Society for Microbiology2024

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system

Melanie Blokesch, Anne-Florence Raphaëlle Bitbol, Simon Bernhard Otto, Richard Marie Servajean, Alexandre Lemopoulos

The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system’s dependency on contact, cellular interactions can lead to either competition or kin protection. Cell-to-ce ...

2024

DNA modifications impact natural transformation of Acinetobacter baumannii

Christian Iseli, Nicolas Jean Philippe Guex, Melanie Blokesch, Nina Vesel, Alexandre Lemopoulos

Acinetobacter baumannii is a dangerous nosocomial pathogen, especially due to its ability to rapidly acquire new genetic traits, including antibiotic resistance genes (ARG). In A. baumannii, natural competence for transformation, one of the primary modes o ...

2023