Publications associées à Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to 129Xe Hyperpolarization Biomedical Imaging Standards

129Xe Dynamic Nuclear Polarization Demystified: The Influence of the Glassing Matrix on the Radical Properties

Rolf Gruetter, Jean-Noël Hyacinthe, Andrea Capozzi, Thanh Phong Kevin Lê, Emma Linnea Wiström

129Xe dissolution dynamic nuclear polarization (DNP) is a controversial topic. The gold standard technique for hyperpolarized xenon magnetic resonance imaging (MRI) is spin exchange optical pumping, which received FDA approval in 2022. Nevertheless, the ve ...

2024

Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples

Andrea Capozzi

As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available hyperpolarization technique for C-13-MRI. Despite the clear path towards personalized medicine that dDNP is paving as an alternative and/or complement to Positron ...

Nature Portfolio2022

Performance and reproducibility of C-13 and N-15 hyperpolarization using a cryogen-free DNP polarizer

Hikari Ananda Infinity Yoshihara, Arianna Ferrari

The setup, operational procedures and performance of a cryogen-free device for producing hyperpolarized contrast agents using dissolution dynamic nuclear polarization (dDNP) in a preclinical imaging center is described. The polarization was optimized using ...

Nature Portfolio2022

Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field

Claudia Christina Zanella

MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR. Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...

EPFL2021

HP agents and biochemical interactions

Hikari Ananda Infinity Yoshihara

The intense but transient increase in nuclear magnetic resonance signal provided by dynamic nuclear polarization (DNP) has enabled a range of new applications, including rapid, minimally-invasive metabolic imaging at the second timescale. This chapter prov ...

Academic Press2021

Metabolic contrast agents produced from transported solid C-13-glucose hyperpolarized via dynamic nuclear polarization

Andrea Capozzi, Arthur César Pinon

Magnetic Resonance Imaging combined with hyperpolarized C-13-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolariz ...

NATURE RESEARCH2021

Efficient Kr/Xe separation from triangular g-C(3)N(4)nanopores, a simulation study

Nicola Marzari, Nicola Colonna, Kumar Varoon Agrawal, Davide Campi, Luis Francisco Villalobos Vazquez de la Parra

Poly(triazine imide) or PTI is a promising material for molecular sieving membranes, thanks to its atom-thick ordered lattice with an extremely high density (1.6 x 10(14)pores per cm(2)) of triangular-shaped nanopores of similar to 0.34 nm diameter. Here, ...

Royal Society of Chemistry2020

UV-Irradiated 2-Keto-(1-C-13)Isocaproic Acid for High-Performance C-13 Hyperpolarized MR

Andrea Capozzi, Arthur César Pinon

Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...

AMER CHEMICAL SOC2020

Xenon Recovery at Room Temperature using Metal-Organic Frameworks

Daniele Ongari

Xenon is known to be a very efficient anesthetic gas, but its cost prohibits the wider use in medical industry and other potential applications. It has been shown that Xe recovery and recycling from anesthetic gas mixtures can significantly reduce its cost ...

Wiley-Blackwell2017

Carbazole as Linker for Dinuclear Gadolinium-Based MRI Contrast Agents

Loïck Moriggi, Lothar Helm, Anne-Sophie Chauvin, Bibimaryam Mousavi

Ligands able to complex two gadolinium ions have been synthesized and characterized in view of the ability of the complexes to increase the spin relaxation of water protons. All ligands are based on the heptadentate diethylenetriaminetetraacetic acid (DTTA ...

Wiley-V C H Verlag Gmbh2017

Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

Arnaud Comment, Rolf Gruetter, Ruud van Heeswijk, Riccardo Balzan, Mor-Miri Mishkovsky

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...

Wiley-Blackwell2016

Methods to hyperpolarize nuclear spins via dissolution and sublimation DNP at high magnetic field

Andrea Capozzi

Dynamic Nuclear Polarization (DNP) is, nowadays, the most well-established and widespread Nuclear Magnetic Resonance (NMR) hyperpolarization technique. With respect to other methods, the main advantage of DNP is, with no doubt, its versatility. In theory e ...

EPFL2016

Spin Noise Detection of Nuclear Hyperpolarization at 1.2K

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud

We report proton spin noise spectra of a hyperpolarized solid sample of commonly used DNP (dynamic nuclear polarization) juice containing TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide) and irradiated by a microwave field at a temperature of 1.2K ...

Wiley-Blackwell2015

What Are the Best Materials To Separate a Xenon/Krypton Mixture?

Berend Smit, Rocio Mercado, Sondre Kvalvag Schnell, Cory Matthew Simon

Accelerating progress in the discovery and deployment of advanced nanoporous materials relies on chemical insight and structure-property relationships for rational design. Because of the complexity of this problem, trial-and-error is heavily involved in th ...

American Chemical Society2015

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Arnaud Comment, Jacques Van Der Klink, Giovanni Boero, Christophe Roussel, Tian Cheng, Tim Rolf Eichhorn, Jean-Noël Hyacinthe, Andrea Capozzi

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Lyndon Emsley

Hyperpolarization of substrates for magnetic resonance spectroscopy (MRS) and imaging (MRI) by dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of polarizing agents (PAs; e.g., persistent radicals embedded in ...

National Academy of Sciences2014

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

Geoffrey Bodenhausen, Sandrine Gerber, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Nicola Salvi, Solène Marcelle Françoise Marie Passemard, Roberto Buratto, Aurélien Laguerre, Daniele Mammoli, Maninder Singh

Transverse and longitudinal relaxation times (T11 and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. ...

Wiley-Blackwell2014

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Arnaud Comment, Christophe Roussel, Mor-Miri Mishkovsky, Tian Cheng, Tim Rolf Eichhorn, Yuhei Takado, Jean-Noël Hyacinthe, Najat Salameh, Andrea Capozzi

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in v ...

National Academy of Sciences2013

Dynamic nuclear polarization of quadrupolar nuclei using cross polarization from protons: surface-enhanced aluminium-27 NMR

Geoffrey Bodenhausen, Pascal Miéville, Marc Anthony Caporini, Diego Carnevale, David Benjamin Roger Antoine Gajan, David Lyndon Emsley, Aaron James Rossini, Moreno Lelli

The surface of gamma-alumina nanoparticles can be characterized by dynamic nuclear polarization (DNP) surface-enhanced NMR of Al-27. DNP is combined with cross-polarization and MQ-MAS to determine local symmetries of Al-27 sites at the surface. ...

Royal Society of Chemistry2012

Development and Understanding of Novel Compounds Designed as Potential MRI Contrast Agents

Hugues Jaccard

The two last decades have witnessed the appearance and the successful development of magnetic resonance imaging (MRI) contrast agents (CAs). Though MRI, which has become an essential medical diagnostic tool, can be performed without contrast agents, its ra ...

EPFL2011