Publications associées à Proceedings of the 2018 next-generation Gamma Knife research meeting

Single-Photon Avalanche Diode Image Sensors for Harsh Radiation Environments

The space industry has experienced substantial growth in recent years, leading to rapid advancements in space exploration and space-based technologies. Consequently, the study of electronics and sensor performance in extreme environments has become crucial ...

EPFL2024

Radiation Patterns of RF Wireless Devices Implanted in Small Animals: Unexpected Deformations Due to Body Resonance

Anja Skrivervik, Stéphanie Lacour, James Daniel Rosenthal, Mingxiang Gao, Kangling Wu, Zvonimir Sipus, German Augusto Ramirez Arroyave

One challenge in designing RF wireless bioelectronic devices is the impact of the interaction between electromagnetic waves and host body tissues on far-field wireless performance. In this paper, we investigate a peculiar phenomenon of implantable RF wirel ...

2023

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

Sebastian Martin Waszak, Li Jiang

H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/ ...

2023

The X-Point radiating regime at ASDEX Upgrade and TCV

Holger Reimerdes, Marco Wischmeier, Christian Gabriel Theiler, Umar Sheikh, Artur Perek, Bernhard Sieglin

Future fusion reactors require a safe, steady-state divertor operation. With deep divertor detachment, which is typically induced by impurity seeding, the radiation concentrates in a small region at the X-point or on closed flux surfaces above the X-point. ...

Elsevier2023

Modulation of the nanoscale motion rate of Candida albicans by X-rays

Sandor Kasas, María Inés Villalba

IntroductionPatients undergoing cancer treatment by radiation therapy commonly develop Candida albicans infections (candidiasis). Such infections are generally treated by antifungals that unfortunately also induce numerous secondary effects in the patient. ...

Frontiers Media SA2023

Vacancy segregation and intrinsic coordination defects at (111) twist grain boundaries in diamond

Christian Brandl, Carolina Baruffi

High radiation damage resistance has become increasingly important for applications of functional materials in harsh environments. The high radiation damage resistance diamond cubic carbon is a unique material which is considered for radiation environments ...

Pergamon-Elsevier Science Ltd2023

Measuring the electron energy distribution in tokamak plasmas from polarized electron cyclotron radiation

Arsène Stéphane Tema Biwole

In this doctoral thesis, a promising technique has been used for the measurement of non-thermal electrons in TCV. The technique employs a Vertical viewing ECE to more easily discriminate the radiation according to the energy of the electrons. Successful ...

EPFL2023

Single-fraction radiosurgery outcomes for large vestibular schwannomas in the upfront or post-surgical setting: a systematic review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines

Constantin Tuleasca

PurposeTo perform a systematic review of literature specific to single-fraction stereotactic radiosurgery (SRS) for large vestibular schwannomas (VS), maximum diameter >= 2.5 cm and/or classified as Koos Grade IV, and to present consensus recommendations o ...

Springer2023

Combined use of intraoperative MRI and awake tailored microsurgical resection to respect functional neural networks: preliminary experience

Constantin Tuleasca

INTRODUCTION: The combined use of intraoperative MRI and awake surgery is a tailored microsurgical resection to respect functional neural networks (mainly the language and motor ones). Intraoperative MRI has been classically considered to increase the exte ...

2023

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Jörg Hülsken

Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1 alpha supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show t ...

CELL PRESS2022

A novel approach for SPICE modeling of light and radiation effects in ICs

Chiara Rossi

Modeling the interaction of ionizing radiation, either light or ions, in integrated circuits is essential for the development and optimization of optoelectronic devices and of radiation-tolerant circuits. Whereas for optical sensors photogenerated carriers ...

EPFL2021

Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial

Constantin Tuleasca

Purpose Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundame ...

2021

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Arnaud Comment, Bernard Lanz, Rolf Gruetter, Cristina Ramona Cudalbu, Mor-Miri Mishkovsky, Jocelyne Bloch

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...

Nature Research2021

Impact of combined use of intraoperative MRI and awake microsurgical resection on patients with gliomas: a systematic review and meta-analysis

Constantin Tuleasca

Microsurgical resection of primary brain tumors located within or near eloquent areas is challenging. Primary aim is to preserve neurological function, while maximizing the extent of resection (EOR), to optimize long-term neurooncological outcomes and qual ...

2021

Design of the third-generation lead-based neutron spallation target for the neutron time-of-flight facility at CERN

Roland Logé, Nicola Colonna, Raffaele Esposito

The neutron time-of-flight (n_TOF) facility at the European Laboratory for Particle Physics (CERN) is a pulsed white-spectrum neutron spallation source producing neutrons for two experimental areas: the Experimental Area 1 (EAR1), located 185 m horizontall ...

2021

Modeling the response of a diamond detector in the zero power reactor CROCUS

Pavel Frajtag, Andreas Pautz, Vincent Pierre Lamirand, Mathieu Hursin, DongHyuk Lee

The present manuscript documents the development of a practical calculation scheme to model the response of a diamond detector in the mixed (neutron and gamma) radiation field of the CROCUS experimental reactor at EPFL. The model is shown to perform reason ...

SPRINGER HEIDELBERG2021

Verification of selective laser melting heat source models with operando X-ray diffraction data

Helena Van Swygenhoven, Steven Van Petegem, Samy Hocine

The output obtained from operando X-ray diffraction experiments on Ti-6Al-4V is used to verify the accuracy of four FEM models in predicting the temperature evolution of the solidified domain, the cooling rates of the alpha and beta phases, and the influen ...

ELSEVIER2021

A New Concept of Sensor for Ultra-high Levels of Radiation based on Radiation Enhanced Oxidation of Copper Thin-films

Georgi Gorine

The Future Circular Collider (FCC) is the envisioned particle accelerator to be installed in the Geneva area (Switzerland). It could achieve an energy of 100 TeV by colliding proton beams (FCC-hh) travelling through a 100 km tunnel. Unprecedented radiation ...

EPFL2020

Humidity Sensors for High Energy Physics Applications: A Review

Sandro Carrara, Amar Kapic, Andromachi Tsirou

Modern silicon-based detectors for high-energy physics operate in an experimental environment with sub-zero temperatures. At those temperatures, even low traces of humidity will produce vapor condensation with damages to the detectors. Monitoring relative ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020