Publications associées à Beam offset impact on the polarization in the CLIC beam delivery system

Precision luminosity measurement at hadron colliders

This thesis links two realms of particle accelerator dynamics and precision particle physics. The achievement of precise luminosity measurement at hadron colliders is enabled with dedicated luminometers. For the Run 3 period, the luminometer upgrade was ...

EPFL2024

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Zhidian Zhang

Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

EPFL2024

Optimizing Dynamic Aperture Studies with Active Learning

Tatiana Pieloni, Massimo Giovannozzi, Ekaterina Krymova, Mike Seidel, Davide Di Croce

Dynamic aperture is an important concept for the study of non-linear beam dynamics in circular accelerators. It describes the extent of the phase-space region where a particle's motion remains bounded over a given number of turns. Understanding the feature ...

Iop Publishing Ltd2024

Hosing of a Long Relativistic Particle Bunch in Plasma

Patrick Blanchard, Ambrogio Fasoli, Ivo Furno, Yanis Andrebe, Alban Sublet, Sun Hee Kim, Riccardo Agnello, Christine Stollberg, Shuai Liu

Experimental results show that hosing of a long particle bunch in plasma can be induced by wakefields driven by a short, misaligned preceding bunch. Hosing develops in the plane of misalignment, selfmodulation in the perpendicular plane, at frequencies clo ...

Amer Physical Soc2024

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Philippe Renaud, Arnaud Bertsch, Clémentine Sophie Sarah Lipp

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

ROYAL SOC CHEMISTRY2023

Evaluation of HPK n plus -p planar pixel sensors for the CMS Phase-2 upgrade

Rakesh Chawla, Albert Perez, François Robert, Andrea Rizzi, Martin Fuchs, Stefano Michelis, Alexis Kalogeropoulos, Varun Sharma, Davide Ceresa, Ashish Sharma, David Vannerom, David Parker, Alessandro Caratelli, Thomas Muller, Yong Yang, Kai Yi, Andromachi Tsirou, Georgios Anagnostou, Konstantin Androsov, Ajay Kumar, Werner Lustermann, Xin Chen, Jing Li

To cope with the challenging environment of the planned high luminosity upgrade of the Large Hadron Collider (HL-LHC), scheduled to start operation in 2029, CMS will replace its entire tracking system. The requirements for the tracker are largely determine ...

Elsevier2023

The Pixel Luminosity Telescope: a detector for luminosity measurement at CMS using silicon pixel sensors

Alexis Kalogeropoulos, Valérie Scheurer, Joanna Malgorzata Wanczyk, André Donadon Servelle

The Pixel Luminosity Telescope is a silicon pixel detector dedicated to luminosity measurement at the CMS experiment at the LHC. It is located approximately 1.75 m from the interaction point and arranged into 16 "telescopes", with eight telescopes installe ...

2023

UAV in the advent of the twenties: Where we stand and what is next

Jan Skaloud, Davide Antonio Cucci

The use of Unmanned Aerial Vehicles (UAVs) has surged in the last two decades, making them popular instruments for a wide range of applications, and leading to a remarkable number of scientific contributions in geoscience, remote sensing and engineering. H ...

2022

Upgraded CMS Fast Beam Condition Monitor for LHC Run 3 Online Luminosity and Beam Induced Background Measurements

The fast Beam Condition Monitor (BCM1F) for the CMS experiment at the LHC was upgraded for precision luminosity measurement in the demanding conditions foreseen for LHC Run3. BCM1F has been rebuilt with new silicon diodes, produced on the CMS Phase 2 Outer ...

2022

Assessing the persistence of chalcogen bonds in solution with neural network potentials

Anne-Clémence Corminboeuf, Veronika Juraskova, Rubén Laplaza Solanas, Frédéric Célerse

Non-covalent bonding patterns are commonly harvested as a design principle in the field of catalysis, supramolecular chemistry, and functional materials to name a few. Yet, their computational description generally neglects finite temperature and environme ...

2022

Generating macrocyclic inhibitors of protein-protein interactions

Gontran Sangouard

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

EPFL2022

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity

Benjamin Marcel Daniel Rothé

Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We present genetic inte ...

Nature Research2021

Low-Latency High-Bandwidth Circuit and System Design for Trigger Systems in High Energy Physics

Marcos Vinícius Silva Oliveira

The increasing luminosity in HEP (High Energy Physics) colliders demands trigger systems to be more selective. First, more information from the detector is routed to the trigger system. Second, larger parts of this information are processed together. These ...

EPFL2021

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture

Francesco Stellacci, Quy Ong Khac, Zhi Luo, Ahmet Bekdemir

Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples fr ...

2020

Establishing a Ternary System for Optical Monitoring of DNA-Protein Interactions with Single-Walled Carbon Nanotubes

Shang-Jung Wu

DNA-protein interactions lie at the crux of life's essential processes. As such, various technologies have been developed to characterize these interactions. The distinct advantages of these technologies can be leveraged to study different facets of these ...

EPFL2020

Analysis of the interaction factor method for energy pile groups with slab

Lyesse Laloui, Melis Sütman, Elena Ravera

The design of energy pile is hampered by the complex interaction between the piles and the slab subjected to thermal loads. Although finite element analysis is used to account explicitly for the interactions, this method is mainly considered as a research ...

2019

Specific Ion Effects at the Interface of Nanometer-Sized Droplets in Water: Structure and Stability

Sylvie Roke, Evangelia Zdrali, Halil Ibrahim Okur

The interaction of ions with interfaces influences numerous processes in chemistry, physics, and biology, while different ion species behave differently at hydrophobic or hydrophilic interfaces. Despite its importance, ion specificity and its relation to s ...

2019

Photoinduced Charge Transfer Dynamics in Blue-Coloured Diketopyrrolopyrrole (DPP) Dye-Sensitized Solar Cells

Heewon Bahng

The inception of push-pull organic dyes utilizing the donor-pi conjugated bridge-acceptor (D-pi-A) motif has created a paradigm shift in the design of efficient nanocrystalline dye-sensitized solar cells (DSSCs), offering control over aesthetic and perform ...

EPFL2019

A novel approach to Landau damping of transverse collective instabilities in future hadron colliders

Michael Schenk

Transverse collective instabilities induced by the beam-coupling impedance of the accelerator structure lead to beam quality degradation and pose a major limitation to the machine performance. Landau damping, a powerful stabilising mechanism that can be em ...

EPFL2019

Metabolic implications of organelle-mitochondria communication

Carlos Canto Alvarez

Cellular organelles are not static but show dynamism-a property that is likely relevant for their function. In addition, they interact with other organelles in a highly dynamic manner. In this review, we analyze the proteins involved in the interaction bet ...

WILEY2019