Publications associées à Ferrocenoyl Pyridine Arene Ruthenium Complexes with Anticancer Properties: Synthesis, Structure, Electrochemistry, and Cytotoxicity

Metal-Free Molecular Catalysts for the Oxygen Reduction Reaction: Electron Affinity as an Activity Descriptor

Ganna Gryn'ova, Juliette Veronique Schleicher

Heteroatom-doped polyaromatic hydrocarbons (or nanographenes) are promising molecular electrocatalysts for the oxygen reduction reaction (ORR). Here, we use density functional theory to investigate the first step of the ORR pathway (chemisorption) for a se ...

AMER CHEMICAL SOC2023

Arene-ruthenium(II) complexes with pyrazole-based ligands bearing a pyridine moiety: Synthesis, structure, DFT calculations, and cytotoxicity

Paul Joseph Dyson, Farzaneh Fadaei Tirani, Mouna Hadiji

Two pyrazole-based ligands bearing a pyridine moiety, 3-methyl-1-(pyridin-2-yl)-5-pyrazolone (HLpy), and 3methyl-1-(pyridin-2-yl)-4-trifluoroacetyl-5-pyrazolone (HQpy,CF3), were prepared and fully characterized in the solid-state and the tautomerism of bot ...

ELSEVIER SCIENCE SA2021

Ligand Effects in Low-Valent Co(I) Clathrochelate Complexes

Kay Severin, Rosario Scopelliti, Farzaneh Fadaei Tirani, Ophélie Marie Planes

Clathrochelate complexes of cobalt are known in the oxidation states I, II, and III. Low-valent Co(I) complexes are highly reactive compounds, and there is only limited knowledge about their structures in the solid state. Herein, we describe the crystallog ...

2021

Divergent Synthesis of Densely Substituted Arenes and Pyridines via Cyclotrimerization Reactions of Alkynyl Triazenes

Kay Severin, Florian Gérald Abela, Nicolai Cramer, Frederick Mark Chadwick, Jin Fay Tan, Carl Thomas Bormann

Densely substituted fused aromatic triazenes can be prepared by [2 + 2 + 2] cyclotrimerization reactions of 1-alkynyl triazenes. The Cp*Ru-catalyzed cyclization proceeds well with both simple alkynyl triazenes and tethered 1-diynyl triazenes. Attractively, ...

2019

Pyrazolium Ionic Liquid Co-catalysts for the Electroreduction of CO2

Paul Joseph Dyson, Dmitry Vasilyev, Erfan Shirzadi

Pyrazolium ionic liquids (Pz ILs) were employed as co-catalysts for electrochemical conversion of CO2 to CO on a silver disk electrode, leading to a significant decrease in the onset potential for the reduction (ca. 500 mV). The electrochemical conversion ...

2018

Synthesis, Structure, and Anticancer Activity of Arene-Ruthenium(II) Complexes with Acylpyrazolones Bearing Aliphatic Groups in the Acyl Moiety

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel

A series of neutral ruthenium(II) arene complexes [(arene)Ru(Q(R))Cl] (arene = p-cymene (cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate Q(R) ligands with different electronic and steric substituents (R = 4-cyclohexyl, 4-stearoyl, or 4-ad ...

American Chemical Society2016

From Sunscreen to Anticancer Agent: Ruthenium(II) Arene Avobenzone Complexes Display Potent Anticancer Activity

Rosario Scopelliti, Paul Joseph Dyson, Tina Riedel, Agnese Petrini

A series of ruthenium(II) arene derivatives (arene = cymene (cym), hexamethylbenzene (hmb)) containing avobenzone (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AVBH) and PTA (1,3,5-triaza-7-phosphaadamantane) or PTA-Me (N-methyl-1,3,5-triaz ...

American Chemical Society2016

Nonsteroidal Anti-inflammatory-Organometallic Anticancer Compounds

Rosario Scopelliti, Paul Joseph Dyson, Emilia Paunescu, Mylène Soudani, Sarah Mcarthur

Compounds that combine metal-based drugs with covalently linked targeted organic agents have been shown, in some instances, to exhibit superior anticancer properties compared to the individual counterparts. Within this framework, we prepared a series of or ...

Amer Chemical Soc2016

A Structure-Activity Study of Nickel NNN Pincer Complexes for Alkyl-Alkyl Kumada and Suzuki-Miyaura Coupling Reactions

Rosario Scopelliti, Xile Hu, Marko Stojanovic, Thomas Clément Di Franco, Sébastien Carlos Keller

A new series of Ni NNN pincer complexes were synthesized and characterized. The main difference among these complexes is the substituents on the side arm amino group(s). No major structural difference was found except for the C-N-C angle of the various sub ...

Wiley-Blackwell2016

Higher generation cationic N,N-ruthenium(II)-ethylene-glycol-derived metallodendrimers: Synthesis, characterization and cytotoxicity

Paul Joseph Dyson, Tina Riedel

A new series of higher generation cationic N,N-chelating, ruthenium(II)-ethylene-glycol metallodendrimers from first-, second-, third- and fourth-generation pyridylimine-based poly(propylene) dendrimer scaffolds of the type, DAB-(NH2) (where n = 4, 8, 16 o ...

Elsevier Science Sa2015

Nickel-Catalyzed Direct Alkylation of Terminal Alkynes at Room Temperature: A Hemilabile Pincer Ligand Enhances Catalytic Activity

Rosario Scopelliti, Pablo Marcelo Perez Garcia, Xile Hu, Peng Ren

Direct coupling of alkyl halides with terminal alkynes provides an efficient and streamlined access to alkyl-substituted alkynes, which are important synthetic intermediates, biologically active molecules, and organic materials. However, until now,there ha ...

American Chemical Society2015

In vivo anti-tumor activity of the organometallic ruthenium(II)-arene complex [Ru(eta(6)-p-cymene)-Cl-2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas

Paul Joseph Dyson, Maxime Dubois, Patrycja Nowak-Sliwinska

Based on the clinical success of platinum-based anti-cancer drugs such as cisplatin, carboplatin and oxaliplatin, a variety of other metal-based anti-cancer compounds are being investigated. In particular, a number of ruthenium-based compounds have been id ...

2014

Potential of Cycloaddition Reactions To Generate Cytotoxic Metal Drugs In Vitro

Paul Joseph Dyson, Stéphanie Crot, Benjamin Samuel Murray, Sviatlana Siankevich

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the devel ...

Amer Chemical Soc2014

Redox couple for electrochemical and optoelectronic devices

Michael Graetzel, Mohammad Khaja Nazeeruddin, Shaik Mohammed Zakeeruddin, Jun Ho Yum, Aswani Yella, Hoi Nok Tsao

The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising ...

2014

Cytotoxicity of ruthenium-arene complexes containing B-ketoamine ligands

Rosario Scopelliti, Paul Joseph Dyson, Catherine Marie Amélie Clavel

New ruthenium(II) arene derivatives (arene = p-cymene, benzene, hexamethylbenzene) containing beta-ketoamine ligands L' (HL' in general; in detail, HLph,ph = (4Z)-3-methyl-4-((phenylamino)(phenyl)methylene)-1-phenyl-1H-pyrazol-5(4H)-one, HLnaph,ph = (4Z)-3 ...

American Chemical Society2013

Naphthalimide-tagged ruthenium-arene anticancer complexes: combining coordination with intercalation

Paul Joseph Dyson, Catherine Marie Amélie Clavel, Fabio Edafe, Kelly Joan Kilpin

Ruthenium(II) arene compounds have been modified with the naphthalimide group, tethered via the arene ligand, i.e. {dichloroeta(6)-N-(phenylalkyl)(4-dimethylamino)-1,8-naphthalimideruthenium(II)} (alkyl = methyl, ethyl, propyl, pta = 1,3,5-triaza-7- ...

American Chemical Society2012

Improved redox couple for electrochemical and optoelectronic devices

Michael Graetzel, Mohammad Khaja Nazeeruddin, Jun Ho Yum, Aswani Yella, Hoi Nok Tsao

The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising ...

2012

Design and Development of Functionalized Cyclometalated Ruthenium Chromophores for Light-Harvesting Applications

Michael Graetzel, Mohammad Khaja Nazeeruddin, Thomas Baumgartner, Aswani Yella

The syntheses and the electrochemical spectroscopic properties of a suite of asymmetrical bistridentate cyclometalated Ru(II) complexes bearing terminal triphenylamine (TPA) substituents are reported. These complexes, which contain structural design elemen ...

2011

Modified friction factor correlation for CICC's based on a porous media analogy

A modified correlation for the bundle friction factor in CICC's based on a porous media analogy is presented. The correlation is obtained by the analysis of the collected pressure drop data measured for 23 CICC's. The friction factors predicted by the prop ...

2011

DNA Reactivity Profile of trans-Platinum Planar Amine Derivatives

Alexey Nazarov

New trans-platinum planar amines (TPAs) represent a family of platinum-based drugs with cytotoxicity equivalent to that of cisplatin, but with negligible cross-resistance. According to the substitution pattern around the metal center, distinct DNA adducts ...

2011